不同类型听阈曲线突发性聋患者血常规相关指标与疗效的关系

叶婷;夏寅;

1:首都医科大学附属北京天坛医院耳鼻喉科

摘要

目的探讨不同类型听阈曲线突发性聋(sudden sensorineural hearing loss,SSHL)患者外周血血小板平均体积(mean platelet volume,MPV)、中性粒细胞/淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)、血小板/淋巴细胞比值(platelet-to-lymphocyte,PLR)与疗效的关系。方法将148例突发性聋患者根据听阈曲线类型分为低频下降型47例,高频下降型22例,平坦下降型58例,全聋型21例。每组再按治疗效果分为有效组和无效组,比较各组患者MPV、NLR、PLR的水平,并与108例正常对照组比较。结果 (1)SSHL组MPV、NLR、PLR均高于正常对照组,不同类型听阈曲线突聋患者各组间MPV、NLR、PLR差异无统计学意义(P>0.05)。低频下降组、平坦下降组MPV高于对照组,差异有统计学意义(P值分别为0.038,0.037);高频下降组、平坦下降组NLR高于对照组,差异有统计学意义(P值分别为0.010,0.035);高频下降组PLR高于对照组,差异有统计学意义(P=0.036)。(2)不同类型听阈曲线SSHL患者治疗有效组和无效组间MPV、NLR、PLR差异均无统计学意义。(3)SSHL患者MPV、NLR、PLR均与预后无关(P>0.05)。结论不同类型听阈曲线SSHL患者血常规MPV、NLR、PLR与其预后均无关。

关键词

突发性聋;血小板平均体积;中性粒细胞/淋巴细胞比值;血小板/淋巴细胞比值;预后

基金项目(Foundation):

首都卫生发展科研专项项目(首发2016-2-2046)资助

作者

叶婷;夏寅;

参考文献

1中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科分会.突发性聋诊断和治疗指南(2015年,济南)[J].中华耳鼻咽喉头颈外科杂志,2006,41:443.

2 Machin SJ,Briggs C.Mean platelet volume:aquick,easy determinant of thrombotic risk[J]?J Thromb Haemost,2010,8:146.

3 Balta S,Demirkol S,Unlu M,et al.Neutrophil to lymphocyte ration may be predict of mortality in all conditions[J].Br J Cancer,2013,109:3125.

4 Durmus K,Terzi H,Karatas TD,et al.Assessment of hematological factors involved in development and prognosis of idiopathic sudden sensorineural hearing loss[J].J Craniofac Surg,2016,27:85.

5 Bláha M,Kosál M,Dr2ata J,et al.Does mean platelet volume really increase in sudden sensorial hearing loss[J]?Eur Arch Otorhinolaryngol,2015,272:2575.

6 Kum RO,Ozcan M,Baklaci D,et al.Investigation of neutrophil-to-lymphocyte ratio and mean platelet volume in sudden hearing loss[J].Braz J Otorhinolaryngol,2015,81:636.

7王秋菊,冰丹.突发性聋的分型诊治与临床研究新进展[J].临床耳鼻咽喉头颈外科杂志,2016,30:1095.

8 Smith J,Siddiq S,Dyer C.et al.Epistaxis in patients taking oral anncoagulant and antiplatelet medication:prospective cohort study[J].J Laryngol Otol,2011,125:38.

9 Chu SG,Becker RC,Berger PB,et a1.Mean platelet volume as a predictor of cardiovascular risk:a systematic review and metaanalysis[J].J Thromb Haemost,2010,8:148.

10 Balta S,Celik T,Mikhailidis DP,et al.The relation between atherosclerosis and the neutrophil-lymphocyte ratio[J].Clin Appl Thromb Hemost,2016,22:405.

11 de Jager CP,Wever PC,Gemen EF,et al.The neutrophillymphocyte count ratio in patients with community-acquired pneumonia[J].PLoS One,2012,7:46561.

12 Yayla C,Acikgoz SK,Yayla KG,et al.The association between platelet-to-lymphocyte ratio and inflammatory markers with the severity of aortic stenosis[J].Biomark Med,2016,10:367.

13 Ganzer U,Albegger KW,Arnold W.Leitlinie“Harsturz”.Konsensusbericht im auftrag des prasidium der deutschen gesellschaft fur hals-nase-ohren-heilkunde,kopf-und hals-chirurgie[J].HNO Information,2004,4:302.

14 Masuda M,Kanzaki S,Minami S,et al.Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss[J].Otol Neurotol,2012,33:1142.

15 Hiramatsu M,Teranishi M,Uchida Y,et al.Polymorphisms in genes involved in inflammatory pathways in patients with sudden sensorineural hearing loss[J].J Neurogenet,2012,26:387.

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突发性聋血小板平均体积中性粒细胞/淋巴细胞比值血小板/淋巴细胞比值预后

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叶婷夏寅