L型钙离子通道的生物学特性及其在听觉功能中的作用
祁繁;陈金;褚汉启;
1:华中科技大学同济医学院附属同济医院耳鼻咽喉头颈外科





1 Barry EL.Expression of mRNAs for the alpha 1subunit of voltage-gated calcium channels in human osteoblast-like cell lines and in normal human osteoblasts[J].Calcif Tissue Int,2000,66:145.
2 Bezanilla F.Voltage sensor movements[J].J Gen Physiol,2002,120:465.
3 Li B,Tadross MR,Tsien RW.Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression[J].Science,2016,351:863.
4 Striessnig J,Bolz HJ,Koschak A.Channelopathies in Cav1.1,Cav1.3,and Cav1.4voltage-gated L-type Ca2+channels[J].Pflugers Arch,2010,460:361.
5 Dolphin AC.Calcium channel diversity:multiple roles of calcium channel subunits[J].Curr Opin Neurobiol,2009,19:237.
6 Wu J,Yan Z,Li Z,et al.Structure of the voltage-gated calcium channel Ca(v)1.1at 3.6Aresolution[J].Nature,2016,537:191.
7 Schlick B,Flucher BE,Obermair GJ.Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons[J].Neuroscience,2010,167:786.
8 Fabiato A.Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum[J].Am J Physiol,1983,245:C1.
9 Moosmang S,Schulla V,Welling A,et al.Dominant role of smooth muscle L-type calcium channel Cav1.2for blood pressure regulation[J].EMBO J,2003,22:6027.
10 Kim SH,Park YR,Lee B,et al.Reduction of Cav1.3channels in dorsal hippocampus impairs the development of dentate gyrus newborn neurons and hippocampal-dependent memory tasks[J].PLoS One,2017,12:e0181138.
11 Wang QM,Xu YY,Liu S,et al.Isradipine attenuates MPTP-induced dopamine neuron degeneration by inhibiting up-regulation of L-type calcium channels and iron accumulation in the substantia nigra of mice[J].Oncotarget,2017,8:47284.
12陈金,周良强,褚汉启,等.Cav1.3钙离子通道在成年大鼠耳蜗的表达[J].听力学及言语疾病杂志,2017,25:630.
13 Chen J,Chu H,Xiong H,et al.Expression patterns of Ca(V)1.3channels in the rat cochlea[J].Acta Biochim Biophys Sin(Shanghai),2012,44:513.
14 Baig SM,Koschak A,Lieb A,et al.Loss of Ca(v)1.3(CACNA1D)function in a human channelopathy with bradycardia and congenital deafness[J].Nat Neurosci,2011,14:77.
15 Torrente AG,Mesirca P,Neco P,et al.L-type Cav1.3channels regulate ryanodine receptor-dependent Ca2+release during sino-atrial node pacemaker activity[J].Cardiovasc Res,2016,109:451.
16 Toyoda F,Mesirca P,Dubel S,et al.CaV1.3L-type Ca2+channel contributes to the heartbeat by generating a dihydropyridine-sensitive persistent Na+current[J].Sci Rep,2017,7:7869.
17 Weiergraber M,Stephani U,Kohling R.Voltage-gated calcium channels in the etiopathogenesis and treatment of absence epilepsy[J].Brain Res Rev,2010,62:245.
18 Doering CJ,Peloquin JB,Mcrory JE.The Ca(v)1.4calcium channel:more than meets the eye[J].Channels(Austin),2007,1:3.
19 Joiner ML,Lee A.Voltage-gated Cav1channels in disorders of vision and hearing[J].Curr Mol Pharmacol,2015,8:143.
20 Sukiasyan N,Hultborn H,Zhang M.Distribution of calcium channel Ca(V)1.3immunoreactivity in the rat spinal cord and brain stem[J].Neuroscience,2009,159:217.
21申卫东,胡吟燕,杨伟炎,等.大鼠耳蜗L-型电压门控钙通道亚型的表达[J].临床耳鼻咽喉科杂志,2004,18:613.
22 Lv P,Kim HJ,Lee JH,et al.Genetic,cellular,and functional evidence for Ca2+inflow through Cav1.2and Cav1.3channels in murine spiral ganglion neurons[J].Neuroscience,2014,34:7383.
23 Zuccotti A,Lee SC,Campanelli D,et al.L-type CaV1.2deletion in the cochlea but not in the brainstem reduces noise vulnerability:implication for CaV1.2-mediated control of cochlear BDNF expression[J].Front Mol Neurosci,2013,6:20.
24 Liang F,Hu W,Schulte BA,et al.Identification and characterization of an L-type Cav1.2channel in spiral ligament fibrocytes of gerbil inner ear[J].Brain Res Mol Brain Res,2004,125:40.
25 Glueckert R,Wietzorrek G,Kammen-Jolly K,et al.Role of class D L-type Ca2+channels for cochlear morphology[J].Hear Res,2003,178:95.
26 Chen J,Chu H,Xiong H,et al.Downregulation of Cav1.3calcium channel expression in the cochlea is associated with age-related hearing loss in C57BL/6Jmice[J].Neuroreport,2013,24:313.
27陈金,褚汉启,周良强,等.L型钙离子通道蛋白α1D亚基与老年性耳聋关系的研究[J].中华老年医学杂志,2014,33:420.
28 Art JJ,Fettiplace R.Variation of membrane properties in hair cells isolated from the turtle cochlea[J].J Physiol,1987,385:207.
29 Lin KH,Oleskevich S,Taschenberger H.Presynaptic Ca2+influx and vesicle exocytosis at the mouse endbulb of Held:a comparison of two auditory nerve terminals[J].J Physiol,2011,589:4301.
30 Koyano K,Funabiki K,Ohmori H.Voltage-gated ionic currents and their roles in timing coding in auditory neurons of the nucleus magnocellularis of the chick[J].Neurosci Res,1996,26:29.
31 Pirone A,Kurt S,Zuccotti A,et al.alpha2delta3is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders[J].J Neurosci,2014,34:434.
32 Liu Y,Zhang H,Li X,et al.Inhibition of voltage-gated channel currents in rat auditory cortex neurons by salicylate[J].Neuropharmacology,2007,53:870.
33 Ebbers L,Satheesh SV,Janz K,et al.L-type calcium channel Cav1.2is required for maintenance of auditory brainstem nuclei[J].J Biol Chem,2015,290:23692.
34谢鼎华,郭运凯,伍伟景,等.庆大霉素对内侧橄榄耳蜗传出神经毒性作用的形态学观察[J].中华耳鼻咽喉科杂志,1999,34:157.
35王枫,赵乌兰.金匮肾气丸对耳聋豚鼠Cav1.2、TNF-α表达的影响[J].新中医,2013,5:175.
36 Jurkovicova-Tarabova B,Griesemer D,Pirone A,et al.Repertoire of high voltage-activated Ca2+channels in the lateral superior olive:functional analysis in wild-type,Ca(v)1.3(-/-),and Ca(v)1.2DHP(-/-)mice[J].J Neurophysiol,2012,108:365.
37 Hirtz JJ,Boesen M,Braun N,et al.Cav1.3calcium channels are required for normal development of the auditory brainstem[J].J Neurosci,2011,31:8280.