大前庭水管综合征患者短潜伏期负反应特征分析

Characteristics of the Acoustically Evoked Short Latency Negative Response in Patients with Large Vestibular Aqueduct Syndrome

卜慧;陈平;吴正规;徐杨龙;邹彬;苏玉佩;

1:广西医科大学第一附属医院耳鼻咽喉头颈外科

2:广西医科大学第四附属医院耳鼻咽喉头颈外科

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摘要

目的探讨大前庭水管综合征(large vestibular aqueduct syndrome,LVAS)患者听性脑干反应(ABR)的声诱发短潜伏期负反应波(acoustically evoked short latency negative response,ASNR)特征,为LVAS患者的临床诊断提供参考。方法对228例(438耳)LVAS患者进行ABR检测,按照ABR引出ASNR与否分为两组,比较不同性别、年龄、耳别、听力下降程度LVAS患者ASNR引出率的差异。结果 228例(438耳)LVAS患者中ASNR引出率为57.08%(250/438),阈值为80～100 dB nHL。不同性别、年龄LVAS患者ASNR的引出率差异无统计学意义(均为P>0.05);不同听力下降程度LVAS患者ASNR的引出率差异有统计学意义(P<0.05),重度和极重度聋患耳ASNR引出率(60.10%,238/396)高于轻度和中度聋患耳(28.57%,12/42)。双耳患病的LAVS患者中,双耳ASNR引出率(45.24%,95/210)高于单耳引出率(26.19%,55/210)。100 dB nHL刺激强度下ASNR平均潜伏期为3.22±0.21 ms,平均振幅为0.39±0.23μV。不同刺激声强度下ASNR的潜伏期、振幅差异有统计学意义(P<0.001),随着刺激声强度增加,ASNR的潜伏期缩短、振幅增大。结论 LVAS患者ASNR引出与否与性别、年龄无关,与单/双耳、听力下降程度有关;随刺激声强度增加,ASNR的潜伏期缩短、振幅增大。

关键词

大前庭水管综合征;声诱发短潜伏期负反应;振幅;听力损失

基金项目(Foundation):

作者

卜慧;陈平;吴正规;徐杨龙;邹彬;苏玉佩;

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