1 Takes RP,Strojan P,Silver CE,et al.Current trends in initial management of hypopharyngeal cancer:the declining use of open surgery[J].Head Neck,2012,34:270.

2 温树信,王斌全.从2014年美国国家综合癌症网诊疗指南看下咽癌的治疗[J].中华肿瘤杂志,2015,37:637.

3 Gupta T,Chopra S,Agarwal JP,et al.Squamous cell carcinoma of the hypopharynx:single-institution outcome analysis of a large cohort of patients treated with primary non-surgical approaches[J].Acta Oncologica,2009,48:541.

4 Iwae S,Fujii M,Hayashi R,et al.Matched pair analysis of patients with advanced hypopharyngeal cancer:surgery versus concomitant chemoradiotherapy[J].Int J Clin Oncol,1997,22:1001.

5 Kuo P,Sosa JA,Burtness BA,et al.Treatment trens and survival effects of chemotherapy for hypopharyngeal cancer:analysis of the National Cancer Data Base[J].Cancer,2016,122:1853.

6 刘武,闫文娴,莫膨涛,等.放疗在头颈部癌症临床治疗中的作用[J].实用肿瘤学杂志,2008,22:282.

7 钱洁,朱江.下咽癌的临床治疗策略[J].临床耳鼻咽喉头颈外科杂志,2017,31:1701.

8 刘亚洲,袁成,施林心,等.放射性粒子植入技术治疗恶性肿瘤进展[J].中国辐射卫生,2018,17:390.

9 中华医学会耳鼻咽喉头颈外科学分会头颈外科学组,中华耳鼻咽喉头颈外科杂志编辑委员会头颈外科组.下咽癌外科手术及综合治疗专家共识[J].中华耳鼻咽喉头颈外科杂志,2017,52:16.

10 谭明,廖天志,向东华.调强适形放疗对鼻咽癌患者治疗效果及免疫功能的影响[J].癌症进展,2019,17:308.

11 高磊,吕庆文,李树祥.适形放疗的新进展—调强放疗[J].医疗设备信息,1999,14:59.

12 蒋勤娟,史雪飞,陈胜东.局部中晚期下咽癌28例放射治疗临床分析[J].全科口腔医学电子杂志,2017,4:73.

13 Tai HC,Hsieh CH,Chao KS,et a1.Comparison of radiotherapy strategies for locally advanced hypopharyngeal cancer after resection and ileocolic flap reconstruction[J].Acta Otolaryngol,2009,129:311.

14 耿志洋,郑宏良.局部晚期下咽癌的治疗进展[J].临床耳鼻咽喉头颈外科杂志,2017,31:732.

15 Jiang YL,Meng N,Wang JJ,et al.CT-guided iodine-125 seed permanent implantation for recurrent head and neck cancers[J].Radiat Oncol,2010,5:68.

16 Krempien RC,Grehn C,Haag C,et al.Feasibility report for retreatment of locally recurrent head-and-neck cancers by combined brachy-chemotherapy using frameless image-guided 3D interstitial brachytherapy[J].Brachytherapy,2005,4:154.

17 Li L,Yang J,Li X,et al.(125) I Seed permanent implantation as a palliative treatment for stage Ⅲ and Ⅳ hypopharyngeal carcinoma[J].Clin Exp Otorhinolaryngol,2016,9:185.

18 陈杰,石峰,黄文孝,等.术中瘤床植入放射性-125I粒子治疗颈部转移性鳞癌[J].中国耳鼻咽喉颅底外科杂志,2016,22:269.

19 陆嘉德,孔琳,高晶,等.质子重离子放射治疗的临床研究概况[J].中华放射医学与防护杂志,2016,36:611.

20 NCCN.The NCCN soft tissue sarcoma clinical practice guidelines in oncology (version 1.2019)[EB/OL].Fort Washington:NCCN,2019[2019-03-06].

21 王军,崔晓波,孔源旻.诱导化疗在局部晚期喉癌下咽癌治疗中的意义[J].临床耳鼻咽喉头颈外科杂志,2016,30:1548.

22 Alterio D,Franco P,Numico G,et al.Non-surgical organ preservation strategies for locally advanced laryngeal tumors:what is the ltalian attitude?Results of a national survey on behalf of AORO and AIOM[J].Medical Oncology,2016,33:76.

23 De Bree R.The current indications for non-surgical treatment of hypopharyngeal cancer[J].Adv Otorhinolaryngol,2019,83:76.

24 李振东,路铁.诱导化疗与手术综合治疗对中晚期下咽癌的疗效比较[J].中华耳鼻咽喉头颈外科杂志,2018,53:918.

25 中国临床肿瘤学会指南工作委员会,主编.中国临床肿瘤学会头颈部肿瘤诊疗指南(2018.V1)[M].北京:人民卫生出版社,2018,58～64.

26 吴文澜,王玥,张园.新辅助化疗在局部晚期下咽癌综合治疗中功能保存作用的研究[J].中国肿瘤外科杂志,2015,7:89.

27 Céruse P,Cosmidis A ,Belot A,et al.A pyriform sinus cancer organ preservation strategy comprising induction chemotherapy with docetaxel,cisplatin,and 5-fluorouracil,followed by potentiated radiotherapy:A multicenter,retrospective study[J].Anti-Cancer Drugs,2014,25:970.

28 Clayman GL,Weber RS,Guillamondegui O,et a1.Laryngeal preservation for advanced laryngeal and hypopharyngeal cancers [J].Arch Otolaryngol Head Neck Surg,1995,121:219.

29 Krstevska V,Stojkovski I,Lukarski D.Concurrent radiochemotherapy in advanced hypopharyngeal cancer [J].Radiation Oncology,2010,5:39.

30 米哲涛,臧志方,张秀甫,等.同期放化疗治疗局部晚期下咽癌的临床观察[J].肿瘤研究与临床,2017,29:773.

31 张丽,宫深谋.同步放化疗治疗局部晚期下咽癌的临床疗效观察[J].医药论坛杂志,2014,35:103.

32 胡兵,魏于全.表皮生长因子受体靶向肿瘤生物治疗[J].癌症,2004,23:471.

33 李召卿,周旋,张仑.表皮生长因子受体在人头颈部鳞状细胞癌中的作用研究进展[J].中国肿瘤临床,2018,45:301.

34 Dietz A,Wichmann G,Kuhnt T,et al.Induction chemotherapy (IC) followed by radiotherapy (RT) versus cetuximab plus IC and RT in advanced laryngeal/hypopharyngeal cancer resectable only by total laryngectomy-final results of the larynx organ preservation trial DeLOS-II [J].Ann Oncol,2018,29:2105.

35 Bonner J,Giralt J,Harari P,et al.Cetuximab and radiotherapy in laryngeal preservation for cancers of the larynx and hypopharynx:a secondary analysis of a randomized clirical lrial[J].JAMA Otolaryngology–Head & Neck Surgery,2016,142:842.