血常规相关指标对突聋患者预后的预测作用

Correlation between Change of Routine Blood Parameters and Prognosis of SSHL Patients

张思林;周文胜;胡仿玲;梁红星;江红群;余杰情;

1:南昌大学第一附属医院耳鼻咽喉头颈外科

摘要

目的探讨突发性聋(sudden sensorineural hearing loss,SSHL)患者平均血小板体积(mean platelet volume,MPV)、中性粒细胞/淋巴细胞比值(neutrophil-to-lymphocyte,NLR)变化与听力下降程度及预后的关系。方法回顾性分析2012年1月至2015年5月172例突发性聋患者的临床资料,分析比较不同听阈曲线类型(低频下降型、平坦下降型、高频下降型及全聋型)及疗效(痊愈、显效、有效和无效)的突聋患者间血常规相关指标(白细胞、中性粒细胞、淋巴细胞、平均血小板体积及中性粒细胞/淋巴细胞比值)的分布特征。结果低频型、平坦型、高频型及全聋型突聋患者血浆MPV、NLR值依次升高,差异有统计学意义(P值分别为0.003和0.01);治疗有效组MPV、NLR明显低于无效组(P<0.01);突聋患者的预后与入院24小时内MPV、NLR负相关,与淋巴细胞计数正相关;NLR和MPV判断预后的敏感度和特异度分别为66.2%和85.5%、58.4%和86.7%。结论突聋患者MPV、NLR与听阈曲线类型和预后有关,入院24时内中NLR可能对预后有较好的预测价值。

关键词

突发性聋;血常规;平均血小板体积;中性粒细胞/淋巴细胞比值;预后

基金项目(Foundation):

江西省教育厅青年项目(GJJ160247);江西省教育厅基金(GJJ150251)资助

作者

张思林;周文胜;胡仿玲;梁红星;江红群;余杰情;

参考文献

1 Rauch SD.Clinical practice.Idiopathic sudden sensorineural hearing loss[J].N Engl J Med,2008,359:833.

2 Ozkan B,Uysal OK,Duran M,et al.Relationship between mean platelet volume and atherosclerosis in young patients with ST elevation myocardial infarction[J].Angiology,2013,64:371.

3 Ulu S,Ulu MS,Bucak A,et al.Neutrophil-to-lymphocyte ratio as a new,quick,and reliable indicator for predicting diagnosis and prognosis of idiopathic sudden sensorineural hearing loss[J].Otol Neurotol,2013,34:1400.

4 Karli R,Alacam H,Unal R,et al.Mean platelet volume:is it a predictive parameter in the diagnosis of sudden sensorineural hearing loss[J]?Indian J Otolaryngol Head Neck Surg,2013,65:350.

5 中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科学分会.突发性聋诊断和治疗指南(2015)[J].中华耳鼻咽喉头颈外科杂志,2015,50:443.

6 Semple JW,Freedman J.Platelets and innate immunity[J].Cell Mol Life Sci,2010,67:499.

7 Rudiger A,Burckhardt OA,Harpes P,et al.The relative lymphocyte count on hospital admission is a risk factor for long-term mortality in patients with acute heart failure[J].Am J Emerg Med,2006,24:451.

8 Bialas M,Taran K,Gryszkiewicz M,et al.Evaluation of neutrophil-lymphocyte ratio usefulness in the diagnosis of appendicitis[J].Wiad Lek,2006,59:601.

9 Torun S,Tunc BD,Suvak B,et al.Assessment of neutrophil-lymphocyte ratio in ulcerative colitis:a promising marker in predicting disease severity[J].Clin Res Hepatol Gastroenterol,2012,36:491.

10 Chen TM,Lin CC,Huang PT,et al.Neutrophil-to-lymphocyte ratio associated with mortality in early hepatocellular carcinoma patients after radiofrequency ablation[J].J Gastroenterol Hepatol,2012,27:553.

11 王春梅,李建新,武欣,等.危重患者血小板平均体积及其膜糖蛋白CD62p的临床研究[J].中国急救医学,2006,26:7.

12 邢英姿,王东海,侯庆军,等.突发性聋患者椎-基底动脉血流动力学观察[J].听力学及言语疾病杂志,2014,22:260.

13 刘涛,王海鹤,宋慧丽.尿激酶对突聋疗效观察[J].中华耳科学杂志,2005,3:295.

14 Suzuki S,Tanaka K,Suzuki N.Ambivalent aspects of interleukin-6in cerebral ischemia:inflammatory versus neurotrophic aspects[J].J Cereb Blood Flow Metab,2009,29:464.

15 Masuda M,Kanzaki S,Minami S,et al.Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss[J].Otol Neurotol,2012,33:1142.

16 Fujioka M,Kanzaki S,Okano HJ,et al.Proinflammatory cytokines expression in noise-induced damaged cochlea[J].J Neurosci Res,2006,83:575.

17 苏钰,乔莉,刘顺利,等.中耳急性炎症对内耳微血管渗透性的影响[J].听力学及言语疾病杂志,2004,22:239.

18 彭易坤,熊世珍,漆一飞,等.突聋患者血液白细胞升高与预后的关系探讨[J].中华耳科学杂志,2005,3:33.

19 周定蓉,甘永莲,徐伟恒,等.以突发性听力损失为首发症状病例的病因探讨[J].听力学及言语疾病杂志,2000,18:12.

本文信息

PDF(389K)

本文关键词相关文章

突发性聋血常规平均血小板体积中性粒细胞/淋巴细胞比值预后

本文作者相关文章

张思林周文胜胡仿玲梁红星江红群余杰情