乙肝病毒携带者与慢性乙肝患者畸变产物耳声发射特征分析

Analysis of Distortion Product Otoacoustic Emissions in Hepatitis B Carrier and Chronic Hepatitis B Patients with Normal Pure Tone Findings

鲍诗平;原晶晶;张帆;

1:首都医科大学附属北京佑安医院耳鼻咽喉头颈外科

在线阅读

摘要

目的探讨纯音听阈正常的乙型肝炎病毒(HBV)携带者与慢性乙型肝炎患者畸变产物耳声发射(distortion product otoacoustic emissions,DPOAE)的特征。方法对纯音听阈正常的HBV携带者29例(HBV携带组,58耳)、慢性乙肝患者30例(慢性乙肝组,60耳)及正常对照组33例(66耳)分别行DPOAE检测,比较三组各频率DPOAE的检出率和幅值差异。结果对照组各频率DPOAE检出率均高于HBV携带组和慢性乙肝组,其中,在553、6 250Hz HBV携带组与对照组差异有统计学意义(P<0.05或P<0.01),在553、783Hz慢性乙肝组与对照组差异有统计学意义(P<0.01);HBV携带组与慢性乙肝组间各频率DPOAE检出率差异无统计学意义(P>0.05)。与对照组比较,慢性乙肝组、HBV携带组各频率DPOAE幅值均下降;HBV携带组各频率DPOAE幅值均高于慢性乙肝组,除553、783Hz外,1 105、1 560、2 211、3 125、4 416、6 250 Hz频率处差异有统计学意义(P<0.05或P<0.01)。结论慢性乙肝组较HBV携带组有潜在的耳蜗功能损失,考虑其肝病的进展与听力损失有一定关系。

关键词

乙肝携带者;慢性乙肝;畸变产物耳声发射

基金项目(Foundation):

作者

鲍诗平;原晶晶;张帆;

参考文献

1黄道,朱韧,张欣欣.慢性乙型肝炎免疫发病机制及免疫治疗[J].中国病毒病杂志,2013,5:233.

2 中华医学会肝病学分会,中华医学会感染病学分会.慢性乙肝防治指南(2010年版)[J].胃肠病学,2011,16:351.

3 Nasab MS,Fathololoomi MR,Alizamir A,et al.Association between hepatitis B and hearing status[J].Oman Medical Journal,2012,27:418.

4 Rao A,Tusler EM,Formo A.Comparison of 2f1-f2DPOAE and 2f2-f1DPOAE fi ne structure in young and middleaged adults[J].International Journal of Audiology,2014,53:165.

5 Job A,Raynal M,Kossowski M.Susceptibility to tinnitus revealed at 2kHz range by bilateral lower DPOAEs in normal hearing subjects with noise exposure[J].Audiol Neurootol,2007,12:137.

6 Job A,Raynal M,Kossowski M,et al.Otoacoustic detection of risk of early hearing loss in ears with normal audiograms:a 3-year follow-up study[J].Hear Res,2009,251:10.

7 Mishra B,Panda N,Singh MP,et al.Viral infections in sudden hearing loss.Do we have enough evidence[J]?Kathmandu Univ Med J,2005,3:230.

8 Lin CY.Hepatitis B virus deoxyribonucleic acid in kidney cellsprobably leading to viral pathogenesis among hepatitis B virusassociated membranous nephropathy patients[J].Nephron,1993,63:58.

9 Bonfils P,Biacabe B,Potard G,et al.Fluctuant perception hearing loss after hepatitis B vaccine[J].Ann Otolaryngol Chir Cervicofac,1996,113:359.

10 Biacabe B,Erminy M,Bonfils P.A case report of fluctuant sensorineural hearing loss after hepatitis B vaccination[J].Auris Nasus Larynx,1997,24:357.

11 Rowe-Jones JM,MacallanDC,Sorooshian M.PolyarteritisNodosa presenting as bilateral sudden onset cochleovestibular failure in a young woman[J].JLaryngol Otol,1990,104:562.

12 Huang CC,Lin WB,Chang PH,et al.Sudden deafness as a presenting symptom of chronic hepatitis B with acute exacerbation[J].Otolaryngol Head Neck Surg,2009,141:659.

13 Sharifian MR,Kamandi S,Sima HR,et al.INF-αand ototoxicity[J].Biomed Res Int,2013,2013:295327.

14 魏来,张恒辉.病毒性肝炎免疫监测研究的新趋势:量化、特异及紧密结合临床[J].中华检验医学杂志,2007,10:1090.

15 何庭宇,卢兰芬,杨山虹,等.乙型肝炎患者不同病期免疫功能指标与肝功能的关系[J].国外医学临床生物化学与检验学分册,2005,8:560.

本文信息

PDF(107K)

本文关键词相关文章

乙肝携带者慢性乙肝畸变产物耳声发射

本文作者相关文章

鲍诗平原晶晶张帆