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丹参对步枪打靶所致急性声损伤的预防作用观察

Preventive Effect of Salvia Miltiorrhiza on Acute Acoustic Trauma Induced by Rifle Shooting

杨传红;李彩红;唐凌媛;刘雲;赖晃文;熊敏;

1:广州总医院医学实验科

2:广州总医院耳鼻咽喉科

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摘要

目的观察丹参对脉冲噪声所致暂时性阈移(temporary threshold shifts,TTS)的影响,探讨丹参对急性声损伤(acute acoustic trauma,AAT)的保护作用。方法 62例新兵训练营的男性士兵随机分为观察组和对照组,每组31例,观察组在训练前连续3天及训练后1天口服丹参片,每次780mg,每天3次;对照组同时间段服用安慰剂(淀粉片)。分别于实弹训练前72 h和训练后6 h对两组受试者右耳行纯音听阈检测,比较两组结果。结果实弹训练前观察组与对照组右耳低频(0.5、1、2 kHz)平均听阈(puretone average,PTA)分别为16.32±6.12、16.21±5.42 dB HL,高频(4、6、8kHz)平均听阈(high pure tone average,HPTA)分别为14.22±5.16、14.89±5.38 dB HL,两组比较差异均无统计学意义(P>0.05)。实弹训练6 h后观察组与对照组右耳低频平均听阈分别为21.88±5.71、21.66±6.62 dB HL,差异无统计学意义(P>0.05);高频平均听阈分别为25.89±7.97、39.75±7.84 dB HL,观察组高频平均听阈和TTS低于对照组(P<0.01)。结论丹参可降低急性声损伤所致的高频TTS,对急性声损伤有潜在的预防作用。

关键词

听力损伤;丹参;噪声

基金项目(Foundation):

国家自然科学基金项目(81470702)

作者

杨传红;李彩红;唐凌媛;刘雲;赖晃文;熊敏;

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听力损伤丹参噪声

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杨传红李彩红唐凌媛刘雲赖晃文熊敏