噪声性聋药物防治研究

邓森林;田春龙;蒋军;陈学敏;张拔渤;徐瑾;薛鑫淼;王小成;

1:空军军医大学基础医学院

2:天水四零七医院耳鼻咽喉科

3:空军军医大学航空航天医学系教育部航空航天医学重点实验室

摘要
<正>据统计,全世界16%的成年人听力下降与噪声暴露有关,噪声性聋(noise induced hearing loss,NIHL)是继老年性聋之后的第二大听觉神经系统损伤性疾病。目前,防治NIHL最好的措施是佩戴听觉防护装置、使用防噪和降噪工艺技术等。然而,由于防护效果的局限性和不舒适性等,这些措施不能完全将环境噪声强度降低到对听觉系统损伤的安全阈值(80dB)之下,所以不能完全有效地防护噪声
关键词
基金项目(Foundation):
国家自然科学基金青年基金(81300836);; 全军后勤科研计划面上项目(CWS13J045)
作者
邓森林;田春龙;蒋军;陈学敏;张拔渤;徐瑾;薛鑫淼;王小成;
参考文献

1 Sliwinska-Kowalska M1,Davis A.Noise-induced hearing loss[J].Noise Health,2012,14:274.

2 Le Prell CG,Dolan DF,Bennett DC,et al.Nutrient plasma levels achieved during treatment that reduces noise-induced hearing loss[J].Transl Res,2011,158:54.

3 Choi CH,Du X,Floyd RA,et al.Therapeutic effects of orally administrated antioxidant drugs on acute noise-induced hearing loss[J].Free Radical Research,2014,48:264.

4 Lindblad AC,Rosenhall U,Olofsson A,et al.The efficacy of N-acetylcysteine to protect the human cochlea from subclinical hearing loss caused by impulse noise:a controlled trial[J].Noise Health,2011,13:392.

5 Lin CY,Wu JL,Shih TS,et al.N-Acetyl-cysteine against noise-induced temporary threshold shift in male workers[J].Hear Res,2010,269:42.

6 Tamir S,Adelman C,Weinberger JM,et al.Uniform comparison of several drugs which provide protection from noise induced hearing loss[J].J Occup Med Toxicol,2010,5:26.

7 Doosti A,Lotfi Y,Moossavi A,et al.Comparison of the effects of N-acetyl-cysteine and ginseng in prevention of noise induced hearing loss in male textile workers[J].Noise Health,2014,16:223.

8 Kapoor N,Mani KV,Shyam R,et al.Effect of vitamin Esupplementation on carbogen-induced amelioration of noise induced hearing loss in man[J].Noise Health,2011,13:452.

9 Raj Guru.Military aircrew and noise-induced hearing loss:prevention and management[J].Aviat Space Environ Med,2013,84:1268.

10 Lin Y1,Kashio A,Sakamoto T,et al.Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs.[J]Neurosci Lett,2011,487:12.

11 Zhou Y,Zheng H,Ruan F,et al.Hydrogen-rich saline alleviates experimental noise-induced hearing loss in guinea pigs[J].Neuroscience,2012,209:47.

12 Quaranta N,Dicorato A,Matera V,et al.The effect of alpha-lipoic acid on temporary threshold shift in humans:a preliminary study[J].Acta Otorhinolaryngol Ital,2012,32:380.

13葛振民,马枢,贾晓青,等.甲硫氨酸性对噪声性听力损伤的保护作用[J].临床耳鼻咽喉头颈外科杂志,2014,28:1232.

14 Xiong M,Wang J,Yang C,et al.The cochlea magnesium content is negatively correlated with hearing loss inducedby impulse noise[J].Am J Otolaryngol,2013,34:209.

15 Gurgen O,Gürgen SG,Kirkim G,et al.Effect of erythropoietin on acoustically traumatized rat cochlea:an immunohistochemical study[J].Anal Quant Cytopathol Histpathol,2014,36:213.

16李艳华,刘移民.抗氧化药物防治噪声聋研究进展[J].中国职业医学,2015,42:579.

17 Staffa P,Cambi J,Mezzedimi C,et al.Activity of coenzyme Q 10(Q-Termulticomposite)on recovery time in noise-induced hearing loss[J].Noise Health,2014,16:265.

18 Fetoni AR,Piacentini R,Fiorita A,et al.Water-soluble coenzymeQ10formulation(Qter)promotes outer hair cell survival in a guinea pig model of noise induced hearing loss(NIHL)[J].Brain Res,2009,1257:108.

19 Li S,Luo Y,Ji X.The neuroprotective effects of combined nimodipine and superoxide dismutase on cerebral ischemia/reperfusion in rats[J].Brain Nerv Dis,2009,17:169.

20 Zhou Y,Zheng G,Zheng H,et al.Primary observation of early transtympanic steroid injection in patients with delayed treatment of noise-induced hearing loss[J].Audiol Neurootol,2013,18:89.

21 Ulf RH,Sebastian S,Irene S,et al.Dexamethasone prevents hearing loss by restoring glucocorticoid receptor expression in the guinea pig cochlea[J].The Laryngoscope,2016,126:29.

22 Fetoni AR,Mancuso C,Eramo SL,et al.In vivo protectiveeffect of ferulic acid against noise-induced hearing loss in theguineapig[J].Neuroscience,2010,169:1575.

23倪坤,黄红彦,冰丹,等.丁咯地尔对噪声性听力损伤影响的实验观察[J].华中科技大学学报(医学版),2007,36:78.

24 Jahani L,Mehrparvar AH,Esmailidehaj M,et al.The effect of atorvastatin on preventing noise-induced hearing loss:an experimental study[J].Int J Occup Environ Med,2016,7:15.

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