1 Honkura Y,Matsuo H,Murakami S,et al.NRF2Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea[J].Sci Rep,2016,6:19329.

2 Coffin AB,Rubel EW,Raible DW.Bax,Bcl2,and p53differentially regulate neomycin-and gentamicin-induced hair cell death in the zebrafish lateral line[J].J Assoc Res Otolaryngol,2013,14:645.

3 Frisina RD,Ding B,Zhu X,et al.Age-related hearing loss:prevention of threshold declines,cell loss and apoptosis in spiral ganglion neurons[J].Aging(Albany NY),2016,8:2081.

4 Monzack EL,Cunningham LL.Lead roles for supporting actors:critical functions of inner ear supporting cells[J].Hear Res,2013,303:20.

5 Munnamalai V,Fekete DM.Wnt signaling during cochlear development[J].Seminars in cell&developmental biology2013,24:480.

6 Waqas M,Zhang S,He Z,et al.Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea[J].Frontiers of Medicine,2016,10:237.

7 Jiang L,Jin R,Xu J,et al.Hair cell regeneration or the expression of related factors that regulate the fate specification of supporting cells in the cochlear ducts of embryonic and posthatch chickens[J].Hear Res,2016,332:17.

8 Zhang Y,Zhai S.Q,Shou J.et al.Isolation,growth and differentiation of hair cell progenitors from the newborn rat cochlear greater epithelial ridge[J].J Neurosci Methods,2007,164(2):271.

9 Hu Z,Luo X,Zhang L,et al.Generation of human inner ear prosensory-like cells via epithelial-to-mesenchymal transition[J].Regen Med,2012,7:663.

10 Li H,Liu H,Heller S.Pluripotent stem cells from the adult mouse inner ear[J].Nat Med,2003,9:1293.

11 Oshima K,Grimm CM,Corrales CE,et al.Differential distribution of stem cells in the auditory and vestibular organs of the inner ear[J].J Assoc Res Otolaryngol,2007,8:18.

12 Chai R,Xia A,Wang T,et al.Dynamic expression of Lgr5,a Wnt target gene,in the developing and mature mouse cochlea[J].J Assoc Res Otolaryngol,2011,12:455.

13 Wang T,Chai R,Kim GS,et al.Lgr5+cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatal mouse utricle[J].Nat Commun,2015,6:6613.

14 He Y,Yu H,Cai C,et al.Inhibition of H3K4me2demethylation protects auditory hair cells from neomycin-induced apoptosis[J].Mol Neurobiol,2015,52:196.

15 Kuo BR,Baldwin EM,Layman WS,et al.In vivo cochlear hair cell generation and survival by coactivation of-catenin and Atoh1[J].Journal of Neuroscience,2015,35:10786.

16 Walters BJ,Coak E,Dearman J,et al.In Vivo Interplay between p27(Kip1),GATA3,ATOH1,and POU4F3Converts non-sensory cells to hair cells in adult mice[J].Cell reports,2017,19:307.

17 White PM,Doetzlhofer A,Lee YS,et al.Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells[J].Nature,2006,441:984.

18 Cox BC,Chai R,Lenoir A,et al.Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo[J].Development(Cambridge,England),2014,141:816.

19 Schimmang T.Expression and functions of FGF ligands during early otic development[J].The International Journal of Developmental Biology,2007,51:473.

20 Wu J,Li W,Lin C,et al.Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles[J].Sci Rep,2016,6:29418.

21 Munnamalai V,Fekete DM.Notch-Wnt-Bmp crosstalk regulates radial patterning in the mouse cochlea in a spatiotemporal manner[J].Development,2016,143:4003.

22 Shi F,Hu L,Jacques BE,et al.beta-Catenin is required for hair-cell differentiation in the cochlea[J].The Journal of Neuroscience:the Official Journal of the Society for Neuroscience,2014,34:6470.

23 Dabdoub A,Puligilla C,Jones JM,et al.Sox2signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea[J].Proc Natl Acad Sci USA,2008,105:18396.

24范晴晴,孟飞龙,房冉,等.Wnt信号通路在毛细胞分化和再生过程中的作用[J].遗传,2017,39:897.

25 Gomez-Orte E,Saenz-Narciso B,Moreno S,et al.Multiple functions of the noncanonical Wnt pathway[J].Trends in genetics:TIG,2013,29:545.

26 Geng R,Noda T,Mulvaney JF,et al.Comprehensive Expression of Wnt signaling pathway genes during development and maturation of the mouse cochlea[J].PLoS One,2016,11:e0148339.

27 Savary E,Sabourin JC,Santo J,et al.Cochlear stem/progenitor cells from a postnatal cochlea respond to Jagged1and demonstrate that notch signaling promotes sphere formation and sensory potential[J].Mech Dev,2008,125:674.

28 Brooker R,Hozumi K,Lewis J.Notch ligands with contrasting functions:Jagged1and Delta1in the mouse inner ear[J].Development(Cambridge,England),2006,133:1277.

29 Liu Z,Owen T,Fang J,et al.Overactivation of Notch1signaling induces ectopic hair cells in the mouse inner ear in an age-dependent manner[J].PLoS One,2012,7:e34123.

30 Mizutari K,Fujioka M,Hosoya M,et al.Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma[J].Neuron,2013,77:58.

31 Lin J,Feng L,Fukudome S,et al.Cochlear stem cells/progenitors and degenerative hearing disorders[J].Curr Med Chem,2007,14:2937.

32 Oshima K,Senn P,Heller S.Isolation of sphere-forming stem cells from the mouse inner ear[J].Methods Mol Biol,2009,493:141.

33钟翠萍,韩宇,黄小段,等.哺乳动物耳蜗发育中的细胞周期调控[J].中华耳科学杂志,2015,13:79.

34 Rocha-Sanchez SM,Beisel KW.Pocket proteins and cell cycle regulation in inner ear development[J].The International Journal of Developmental Biology,2007,51:585.

35 Sage C,Huang M,Karimi K,et al.Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein[J].Science,2005,307:1114.

36 Kelly MC,Chang Q,Pan A,et al.Atoh1directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo[J].The Journal of Neuroscience,2012,32:6699.

37 Kiernan AE.Notch signaling during cell fate determination in the inner ear[J].Seminars in cell&Developmental Biology,2013,24:470.

38 Zhai S,Shi L,Wang BE,et al.Isolation and culture of hair cell progenitors from postnatal rat cochleae[J].J Neurobiol,2005,65:282.收稿