绝经女性良性阵发性位置性眩晕患者骨密度、血钙浓度及维生素D水平分析

Analysis of Bone Mineral Density,Serum Calcium Concentration and Vitamin D Status in Postmenopausal Women with Benign Paroxysmal Positional Vertigo

张秀玲;周宁霞;陈金湘;吴海燕;

1:东南大学医学院附属江阴医院耳鼻咽喉科

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摘要

目的探讨绝经后女性良性阵发性位置性眩晕(benign paroxysmal positional vertigo,BPPV)患者BPPV的发生和复发与骨密度、血钙及血清维生素D浓度的相关性。方法选取2014年1月至2016年12月就诊于东南大学附属江阴医院耳鼻喉科门诊且明确诊断为原发性BPPV的78例(78耳)绝经后女性患者为试验组,根据随访结果分为BPPV未复发组(63例)和BPPV复发组(15例),选取同期来院体检的自然绝经1年的正常女性30例为对照组。采用双能射线吸收法检测所有受试者腰椎骨密度,抽取清晨空腹外周静脉血4ml,分别运用半自动分析仪和免疫化学发光法检测血钙浓度和血清维生素D水平。比较各组间骨密度、血钙浓度和血清维生素D水平。结果试验组骨密度下降者占82.15%(64/78),高于对照组(23.33%,7/30),差异有统计学意义(P<0.001)。BPPV复发组骨密度T值最低(-1.77±0.63),其次为BPPV未复发组(-1.29±0.82),对照组为-0.63±0.92,组间差异有统计学意义(P<0.001)。三组间的血钙浓度差异无统计学意义(P=0.71)。对照组的血清维生素D水平(23.98±2.12ng/ml)高于BPPV未复发组(18.45±4.28ng/ml)和BPPV复发组(17.15±6.04)ng/ml,差异有统计学意义(P<0.001),BPPV未复发组与复发组之间差异无统计学意义(P>0.05)。结论绝经后女性BPPV患者BPPV的发生可能与骨密度及血清维生素D水平下降有关,而与血钙浓度可能无关;绝经后女性患者BPPV的复发则仅与骨密度下降有关。

关键词

良性阵发性位置性眩晕;绝经;骨密度;血钙;维生素D

基金项目(Foundation):

无锡市卫生计生科研项目(MS201714)

作者

张秀玲;周宁霞;陈金湘;吴海燕;

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张秀玲周宁霞陈金湘吴海燕