经甲状舌骨膜声带注射糖皮质激素治疗喉接触性肉芽肿

田师宇;李进让;李可亮;郭红光;张昊;邹世桢;

1:南方医科大学第三临床医学院

2:海军总医院全军耳鼻咽喉头颈外科中心

摘要
目的初步探索经甲状舌骨膜(transthyrohyoid membrane approach,TH)声带注射术治疗喉接触性肉芽肿(又称声带突肉芽肿)的临床应用价值。方法回顾性分析2013年2月至2015年10月经TH径路声带病变内糖皮质激素注射术(醋酸曲安奈德注射液0.31mg,一次/月,至病变消失)配合抑酸疗法(口服埃索美拉唑片,20mg/次,早晚饭前半小时各一次)治疗的32例(34侧)喉接触性肉芽肿(laryngeal contact granuloma,LCG)患者的临床资料,随访141mg,一次/月,至病变消失)配合抑酸疗法(口服埃索美拉唑片,20mg/次,早晚饭前半小时各一次)治疗的32例(34侧)喉接触性肉芽肿(laryngeal contact granuloma,LCG)患者的临床资料,随访1444个月,中位时间26个月。应用Image J图像处理软件对患者病变组织范围进行测量,通过计算其与自身声带长度的比值来判断病变大小,分析其疗效。结果 32例34侧病变经TH法声带突肉芽肿注射曲安奈德,分别为144个月,中位时间26个月。应用Image J图像处理软件对患者病变组织范围进行测量,通过计算其与自身声带长度的比值来判断病变大小,分析其疗效。结果 32例34侧病变经TH法声带突肉芽肿注射曲安奈德,分别为16次,中位数3次,共113次,一次穿刺注射成功率100%,未出现并发症;治愈率64.71%(22/34),总有效率94.12%(32/34);疗程16次,中位数3次,共113次,一次穿刺注射成功率100%,未出现并发症;治愈率64.71%(22/34),总有效率94.12%(32/34);疗程17月,平均3.32±1.34月。结论经TH法声带病变内糖皮质激素注射术配合抑酸疗法治疗喉接触性肉芽肿疗效确切,操作简便、准确,成功率高,疗程短,副作用少。
关键词
声带注射术;甲状舌骨膜;喉接触性肉芽肿;激素
基金项目(Foundation):
作者
田师宇;李进让;李可亮;郭红光;张昊;邹世桢;
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