蛋白磷酸酶1在D-半乳糖诱导老化小鼠耳蜗中的表达
The Role of PP1 in the Cochlea of Mimetic Aging Mice Induced by D-galactose
许涛;马婷婷;吴喜迪;刘双月;
1:锦州医科大学生命科学研究院
2:锦州医科大学生理学教研室
1 Crajoinas RO,Pessoa TD,Rodrigues MV,et al.Changes in the actixity and expression of protein phosphatase-1accompany the differentinal regulation of NHE3before and after the onset of hypertension in spontaneously hypertensive rats[J].Acta Physiol(Oxf),2014,10:11111.
2 Choy MS,Hieke M,Kumar GS,et al.Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1regulatory code[J].Proc Natl Acad Sci USA,2014,111:4097.
3 Li DW,Liu JP,Schmid PC,et al.Protein serine/threonine phosphatase-1dephosphorylates p53at Ser-15and Ser-37to modulate its transcriptional and apoptotic activities[J].Oncogene,2006,25:3006.
4 Lee SJ,Lim CJ,Min JK,et al.Protein phosphatase 1nuclear targeting subunit is a hypoxia inducible gene:its role in posttranslational modification of p53and MDM2[J].Cell Death Differ,2007,14:1106.
5 吴喜迪,张俏,李文静,等.PNUTS在D-半乳糖诱导老化小鼠耳蜗中的表达[J].天津医药,2016,44:1078.
6 Wu L,Sun Y,Hu YJ,et al.Increased p66Shc in the inner ear of D-galactose-induced aging mice with accumulation of mitochondrial DNA 3873-bp deletion:p66Shc and mtDNA damage in the inner ear during aging[J].PLos One,2012,7:e50483.
7 韩晶,骞爱荣,胡丽芳,等.基于免疫荧光图像的微管蛋白半定量分析[J].第四军医大学学报,2009,30:2901.
8 Toon V,Janina G,Iris V,et al.Genome-wide promoter binding profiling of protein phosphatase-1and its major nuclear targeting subunits[J].Nucleic Acids Research,2015,43:5771.
9 Gabriel De L,Tara CS,Nancy AK.Reduced expression of PNUTS leads to activation of Rb-phosphatase and casepasemediated apoptosis[J].Cancer Biology&Therapy,2008,7:833.
10 沈亚峰,袁青宁,汤莹,等.心力衰竭时大鼠心肌细胞肌浆网钙回摄的变化[J].电子显微学报,2015,34:55.
11 Kavela S,Shinde SR,Ratheesh R,et al.PNUTS functions as a proto-oncogene by sequestering PTEN[J].Cancer Res,2013,73:205.