斑马鱼听觉诱发电位检测系统的建立和应用
Establishment and Application of Zebrafish Auditory Evoked Potential(AEP) Detection System
潘豪来;王际平;于栋帧;杨光;时海波;王坚;殷善开;
1:上海交通大学附属第六人民医院耳鼻咽喉头颈外科
2:加拿大达尔豪斯大学人类交流障碍学院





1 Steiner AB,Kim T,Cabot V,et al.Dynamic gene expression by putative hair-cell progenitors during regeneration in the zebrafish lateral line[J].Proc Natl Acad Sci USA,2014,111:E1393.
2 Higgs DM,Rollo AK,Souza MJ,et al.Development of form and function in peripheral auditory structures of the zebrafish(Danio rerio)[J].J Acoust Soc Am,2003,113:1145.
3 Zeddies DG,Fay RR.Development of the acoustically evoked behavioral response in zebrafish to pure tones[J].J Exp Biol,2005,208:1363.
4 Higgs DM,Souza MJ,Wilkins HR,et al.Age-and sizerelated changes in the inner ear and hearing ability of the adult zebrafish(Danio rerio)[J].J Assoc Res Otolaryngol,2002,3:174.
5 Kenyon TN,Ladich F,Yan HY.A comparative study of hearing ability in fishes:the auditory brainstem response approach[J].J Comp Physiol A,1998,182:307.
6 Yan HY,Fine ML,Horn NS,et al.Variability in the role of the gasbladder in fish audition[J].J Comp Physiol A,2000,186:435.
7 Smith ME,Kane AS,Popper AN.Noise-induced stress response and hearing loss in goldfish(Carassius auratus)[J].J Exp Biol,2004,207:427.
8 Lechner W,Wysocki LE,Ladich F.Ontogenetic development of auditory sensitivity and sound production in the squeaker catfish synodontis schoutedeni[J].BMC Biol,2010,8:10.
9 Nicolson T.The genetics of hearing and balance in zebrafish[J].Annu Rev Genet,2005,39:9.
10 Vlasits AL,Simon JA,Raible DW,et al.Screen of FDAapproved drug library reveals compounds that protect hair cells from aminoglycosides and cisplatin[J].Hear Res,2012,294:153.
11 Jiang L,Romero-Carvajal A,Haug JS,et al.Gene-expression analysis of hair cell regeneration in the zebrafish lateral line[J].Proc Natl Acad Sci USA,2014,111:E1383.
12 Monroe JD,Manning DP,Uribe PM,et al.Hearing sensitivity differs between zebrafish lines used in auditory research[J].Hear Res,2016,341:220.
13 Trapani JG,Nicolson T.Physiological recordings from zebrafish lateral-line hair cells and afferent neurons[J].Methods Cell Biol,2010,100:219.