1 World Health Organization.Deafness and hearing loss.2015;http://www.who.int/mediacentre/factsheets/fs300/zh/.

2 Cotanche DA.Genetic and pharmacological intervention for treatment/prevention of hearing loss[J].Journal of Communication Disorders,2008,41:421.

3 Zheng J,Shen W,He DZZ,et al.Prestin is the motor protein of cochlear outer hair cells[J].Nature,2000,405:149.

4 Dallos P,Fakler B.Prestin,a new type of moter protein[J].Nature Reviews Molecular Cell Biology,2002,3:104.

5 Liberman MC,Gao J,He DZZ,et al.Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier[J].Nature,2002,419:300.

6陈秉,夏源,王海涛,等.噪声性听力损失与耳蜗外毛细胞Prestin蛋白的相关性分析[J].中国工业医学杂志,2015,28:92.

7 Xia A,Song Y,Wang R,et al.Prestin regulation and function in residual outer hair cells after noise-induced hearing loss[J].Plos One,2013,8:e82602.

8王军义,邹志辉,陈晓滨,等.噪声性听力损伤对豚鼠Prestin蛋白及mRNA表达水平影响[J].中国职业医学,2014,41:384.

9 Yang C,Zhang W,Liu X,et al.Localization of prestin and expression in the early period after radiation in mice[J].European Archives of Oto-Rhino-laryngology,2014,271:3333.

10 Zheng J,Madison LD,Oliver D,et al.Prestin,the motor protein of outer hair cells[J].Audiology and Neurotology,2002,7:9.

11 Vega RB,Matsuda K,Oh J,et al.Histone deacetylase 4controls chondrocyte hypertrophy during skeletogenesis[J].Cell,2004,119:555.

12 Belyantseva IA,Adler HJ,Curi R,et al.Expression and localization of Prestin and the sugaar transport GLUT-5during development of electromotility in cochlear outer hair cells[J].The Journal of Neuroscience,2000,20:RC116.

13 Zheng J,Long KB,Shen W,et al.Prestin topology:localization of protein epitopes in relation to the plasma membrane[J].Nuroreport,2001,12:1929.

14 Brownell WE,Bader CR,Bertrand D,et al.Evoked mechanical responses of isolated cochlear outer hair cells[J].Science,1985,227:194.

15 Dallos P,Evans BN.High-frequency motility of outer hair cells and the cochlear amplifier[J].Science,1995,267:2006.

16 He DZZ,Jia S,Sato T,et al.Changes in plasma membrane structure and electromotile properties in prestin deficient outer hair cells[J].Cytoskeleton,2010,67:43.

17王显红,张博,尹时华.不同日龄乳鼠耳蜗外毛细胞底部Prestin蛋白的分布[J].听力学及言语疾病杂志,2013,21:407.

18 Gross J,Stute K,Fuchs J,et al.Effects of retinoic acid and butyric acid on the expression of Prestin and Gata-3in organotypic cultures of the organ of corti of newborn rats[J].Developmeantal Neurobiology,2011,72:650.

19 Judice TN,Nelson NC,Beisel CL,et al.Cochlear whole mount in situ hybridization:identification of longitudinal and radial gradients[J].Brain Research Protocols,2002,9:65.

20 Yu N,Zhu ML,Johnson B,et al.Prestin up-regulation in chronic salicylate(aspirin)administration:An implication of functional dependence of Prestin expression[J].Cellular and Molecular Life Sciences,2008,65:2407.

21 Weber T,Zimmermann U,Winter H,et al.Thyroid hormone is a critical determinant for the regulation of the cochlear motor protein prestin[J].Proceedings of the National Academy of Sciences,2002,99:2901.

22 Winter H,Braig C,Zimmermann U,et al.Thyroid hormone receptors TRα1and TRβdifferentially regulate gene expression of Kcnq4and prestin during final differentiation of outer hair cells[J].Cell Science,2006,19:2975.

23 Richter CP,Munscher A,Santana MD,et al.Complete activation of thyroid hormone receptorβby T3is essential for normal cochlear function and morphology in mice[J].Celluar Physiology and Biochemistry,2011,28:997.

24 Park C,Thein P,Kalinec G,et al.HEI-OC1cells as a model for investigating Prestin function[J].Hearing Research,2016,335:9.

25 Gross J,Angerstein M,Fuchs J,et al.Expression analysis of Prestin and selected transcription facors in newborn rats[J].Cellular and Molecular Neurobiology,2011,31:1089.

26 Farnham PJ.Insights from genomic profiling of transcription factors[J].Nature Reviews Genetics,2009,10:605.

27 Gross J,Stute K,Moller R,et al.Expression of prestin and Gata-3,-2,-1mRNA in the rat organ of Corti during the postnatal period and in culture[J].Hearing Research,2010,261:9.

28 Gulyaeva LF,Kushlinskiy NE.Regulatory mechanisms of microRNA expression[J].Journal of Translational Medicine,2016,14:143.

29 Menca,Modamio-Hybjr S,Redshaw N,et al.Mutations in the seed region of human miR-96are responsible for nonsyndromic progressive hearing loss[J].Nature Genetics,2009,41:609.

30 Lewis MA,Quint E,Glazier AM,et al.An ENU-induced mutation of miR-96associated with progressive hearing loss in mice[J].Nature Genetics,2009,41:614.

31 Huyghe A,Van den Ackerveken P,Sacheli R,et al.MicroRNA-124 Regulates Cell Specification in the Cochlea through Modulation of Sfrp4/5[J].Cell Reports,2015,13:31.

32 Riccardi S,Bergling S,Sigoillot F,et al.MiR-210promotes sensory hair cell formation in the organ of corti[J].BMC Genomics,2016,17:309.

33 Zheng J,Anderson CT,Miller KK,et al.Identifying components of the hair-cell interactome involved in cochlear amplification[J].BMC Genomics,2009,10:127.

34 Alpy F,Rousseau A,Schwab Y,et al.STARD3or STARD3NLand VAP form a novel molecular tether between late endosomes and the ER[J].J Cell Sci,2013,126:5500.

35 Sengupta S,Miller KK,Homma K,et al.Interaction between the motor protein prestin and the transporter protein VAPA[J].Biochimica et Biophysica Acta(BBA)-Molecular Cell Research,2010,1803:796.

36 He DZZ,Cheatham MA,Pearce M,et al.Mouse outer hair cells lacking theα9ACh receptor are motile[J].Developmental Brain Research,2004,148:19.

37 Song Y,Xia A,Lee Hee Y,et al.Activity-dependent regulation of prestin expression in mouse outer hair cells[J].Journal of Neurophysiology,2015,113:3531.

38 Mazurek B,Fuchs J,Stute K,et al.Decrease of prestin expression by increased potassium concentration in organotypic cultures of the organ of Corti of newborn rats[J].Neuroscience Letters,2011,499:52.

39 Zhao H,Santos-Sacchi J.Auditory collusion and a coupled couple of outer hair cells[J].Nature,1999,399:359.

40 Harasztosi C,Gummer AW.The chloride-channel blocker 9-anthracenecarboxylic acid reduces the nonlinear capacitance of prestin-associated charge movement[J].European Journal of Neuroscience,2016,43:1062.

41 Takahashi S,Homma K,Zhou Y,et al.Susceptibility of outer hair cells to cholesterol chelator 2-hydroxypropyl-β-cyclodextrine is prestin-dependent[J].Scientific Reports,2016,6:21973.