老年性聋患者听觉事件相关电位特征分析

The Characteristics of Auditory Event-related Potential in Presbycusis Patients

景艳;梁建平;彭璐;陈睿春;

1:广西壮族自治区人民医院耳鼻咽喉科

摘要
目的初步研究老年性聋患者的听觉事件相关电位(auditory event-related potential,AERP)失匹配负波(mismatch negativity,MMN)和P300的变化特征。方法采用oddball刺激序列,对20例健康青年志愿者(对照组)、20例老年听力正常者(老年听力正常组)和20例老年性聋患者(老年性聋组)进行AERP测试,在阅读状态下获得MMN波形,在集中注意力计数状态下获得P300波形,比较三组MMN、P300波形的潜伏期和波幅。结果老年性聋组MMN潜伏期为187.38±29.63 ms,与老年听力正常组(160.10±23.21 ms)和对照组(148.22±19.30 ms)相比明显延长(P<0.01),老年听力正常组潜伏期与对照组比较差异有统计学意义(P<0.05),三组MMN波幅差异无统计学意义(P>0.05);老年性聋组P300潜伏期为369.83±27.09,较老年听力正常组(332.89±25.60 ms)和对照组(318.51±22.32 ms)明显延长(P<0.01),三组P300波幅差异无统计学意义(P>0.05)。结论老年性聋患者听觉中枢功能受损,认知功能减退,MMN、P300可作为评估老年性聋患者听觉中枢功能、认知功能的客观检查方法。
关键词
老年性聋;听觉事件相关电位;失匹配负波;P300
基金项目(Foundation):
广西壮族自治区卫生厅自筹经费科研课题(Z2014619)
作者
景艳;梁建平;彭璐;陈睿春;
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景艳梁建平彭璐陈睿春