巨细胞病毒感染肺炎婴幼儿听力检测结果分析

The Clinical Audiological Characteristics of Infants with Human Cytomegalovirus Pneumonia

翁美玲;高黎;耿刚;徐洁;

1:重庆医科大学附属儿童医院耳鼻咽喉科

2:儿童发育疾病研究教育部重点实验室

3:儿童发育重大疾病国家国际科技合作基地

4:重庆医科大学附属儿童医院呼吸科

摘要
目的探讨人巨细胞病毒(human cytomegalovirus,HCMV,简称CMV)感染肺炎婴幼儿的听力学特点。方法以确诊为CMV感染肺炎婴幼儿(CMV感染组)115例(230耳)为研究对象,并选取同期非CMV感染肺炎婴幼儿(非CMV感染组)115例(230耳)以及健康婴幼儿115例(230耳)(对照组),分别进行听性脑干反应(auditory brainsen response,ABR)、声导抗测试,比较三组的结果及听力随访情况。结果CMV感染组50耳(21.74%)、非CMV感染组34耳(14.78%)、健康对照组17耳(7.39%)ABR波V阈值>30dB nHL(P<0.05);CMV感染组感音神经性听力损失检出率(16.96%,39/230)高于非CMV感染组(6.52%,15/230)和健康对照组(1.74%,4/230)(P<0.05);CMV感染组(8.70%,20/230)、非CMV感染组(12.17%,28/230)声导抗异常耳均高于健康对照组(2.61%,6/230),CMV感染组、非CMV感染组组间差异无统计学意义(P>0.05);随访3年,CMV感染组有3例感音神经性听力损失者听力恢复正常,各组其余感音神经性听力损失患儿听力无改善,各组传导性听力损失者均恢复正常。结论 CMV感染肺炎婴幼儿感音神经性聋发病率高,CMV感染肺炎容易导致中耳功能异常引起ABR反应阈升高;对于CMV感染肺炎婴幼儿需要行综合听力学检测且长期随访。
关键词
人巨细胞病毒;肺炎;听性脑干反应;婴幼儿
基金项目(Foundation):
作者
翁美玲;高黎;耿刚;徐洁;
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