不同强度非靶刺激声对听觉事件相关电位P300的影响

The Effects of Different in Nontarget Stimulus Intensity on Auditory Event-related Potential P300

景艳;陈睿春;梁建平;

1:广西壮族自治区人民医院耳鼻咽喉科

摘要

目的比较不同强度非靶刺激声诱发的听觉事件相关电位(auditory event-related potential,AERP)P300波潜伏期和幅值,探讨相同频率刺激声条件下诱导典型P300波形所需的靶刺激和非靶刺激声强度。方法对20例健康青年志愿者,均采用相同的短纯音靶刺激声(1kHz,60dB nHL)和三种不同强度(50、65、70dB nHL,1kHz)的非靶刺激声(短纯音)进行3次AERP测试,比较其P300的潜伏期和幅值。结果每例受试者均能诱发出P300,70、65、50dB nHL非靶刺激声强度下,P300潜伏期分别为316.25±21.16、320.83±22.64、318.44±25.82ms,差异无统计学意义(P>0.05);幅值分别为5.02±2.04、7.42±2.58、3.54±2.23μV,65dB nHL所诱发的P300幅值显著大于70和50dB nHL所诱发的幅值,差异有统计学意义(P<0.01),70和50dB nHL所诱发的P300幅值差异无统计学意义(P>0.05)。结论改变非靶刺激声强度对P300波潜伏期无明显影响,但能显著改变幅值;相同频率刺激声条件下,靶刺激和非靶刺激声强度分别为60dB nHL和65dB nHL时能诱发出典型的P300波形。

关键词

听觉事件相关电位;P300;诱发电位;声刺激

基金项目(Foundation):

广西壮族自治区卫生厅自筹经费科研课题(Z2014619)

作者

景艳;陈睿春;梁建平;

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听觉事件相关电位 P300 诱发电位声刺激

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景艳陈睿春梁建平