Nrf2及其信号通路相关因子在噪声性聋大鼠耳蜗的表达
Expression of Nrf2 and Its Related Factors in the Cochlea of Rats with Noise Induced Hearing Loss
蔡蔚然;郑贵亮;葛萨萨;张国平;周义德;
1:第二军医大学长海医院耳鼻咽喉-头颈外科
2:上海远洋医院耳鼻咽喉科





1 Henderson D,Bielefeld EC,Harris KC,et al.The role of oxidative stressin noise-induced hearing loss[J].Ear Hear,2006,27:1.
2 Lee JM,Johnson JA.An important role of Nrt2-ARE pathway in the cellular defense mechanism[J].J Biochem Mol Biol,2004,37:139.
3 Tomofumi H,Keiji T,Bungo N,et al.Protective role of Nrf2in age-related hearing loss and gentamicin ototoxicity[J].Biochem Biophys Res Commun,2011,415:94.
4 Liwei C,Ning Y,Yan L,et al.Hydrogen-saturated saline protects intensive narrow band noise-induced hearing loss in guinea pigs through an antioxidant effect[J].PLoS One,2014,9 :e100774.
5 Rewerska A,Pawelczyk M,Rajkowska E,et al.Evaluating Dmethionine dose to attenuate oxidative stress-mediated hearing loss following over exposure to noise[J].Eur Arch Otorhinolaryngol,2013,270:1513.
6 Teru K,Chisato F,Tatsuya Y.Reactive oxygen species,apoptosis,and mitochondrial dysfunction in hearing loss[J].Bio Med Res Int,2015,617207.
7 Kaspar JW,Niture SK,Jaiswal AK.Nrf2:Nrf2(Keap1)signaling in oxidative stress[J].Free Radic Biol Med,2009,47:1304.
8 Klaassen CD,Reisman SA.Nrf2the rescue:efects of the antioxidative/electrophilic response on the liver[J].Toxicol Appl Pharmacol,2010,244:57.
9 Brown SL,Sekhar KR,Rachakonda G,et al.Activating transcription factor 3is a novel repressor of the nuclear factor erythroid-derived 2-related factor2(Nrf2)regulated stress pathway[J].Cancer Res,2008,68:364.
10 Fetoni AR,Paciello F,Rolesi R,et al.Rosmarinic acid upregulates the noise-activated Nrf2/HO-1pathway and protects against noise-induced injury in rat cochlea[J].Free Radical Bio Med,2015,85:269.
11 Jose CJ,Mari M,Mark EB,et al.Superoxide dismutase 1(SOD1)is essential for H202-mediated oxidation and inactivation of phosphatases in growth factor signaling[J].Proc Natl Acad Sci USA,2008,105:7147.
12 Turrens JF.Mitochondrial formation of reactive oxygen species[J].The Journal of Physiology,2003,552:335.
13 Gozzelino R,Jeney V,Soares MP.Mechanisms of cell protection by heme oxygenase-1[J].Annu Rev Pharmacol Toxicol,2010,50:323.
14 Chen JQ,Madeleine RH,Michelle A,et al.Absolute quantitation of endogenous proteins with precision and accuracy using a capillary Western system[J].Anal Biochem,2013,442:97.