连续鼓室注射糖皮质激素初始治疗突发性聋的效果分析

张宇;高中;刘亚军;杨皖菁;周波;李丹;肖键;王勇;

1:湖北医药学院附属东风医院耳鼻咽喉头颈外科

摘要
目的探讨连续鼓室注射糖皮质激素作为突发性聋初始治疗的疗效。方法将91例(91耳)突发性聋患者随机分为鼓室注射组42例(42耳)和口服组49例(49耳),鼓室注射组采用甲强龙鼓室注射,每天一次,共7天;口服组采用口服强的松片,疗程14天,两组对象分别于治疗前及治疗后第1、2、4、8周测试纯音听阈,所有病例听力随访至少8周。结果在第1、2周,鼓室注射组纯音听阈均值分别为61.57±24.82、56.76±25.06dB HL,而口服组分别为71.90±19.22、66.47±19.77dB HL,差异均有统计学意义(均为P<0.05);在第1、2、4周鼓室注射组(听力分别提高15.38±14.11、20.19±13.83、23.36±13.87dB,优于口服组(分别为6.18±8.07、11.57±9.16、17.88±11.76dB)(均为P<0.05);在治疗第1周结束后,鼓室注射组痊愈6例(14.29%,6/42),总有效14例(33.33%,14/42),口服组痊愈1例(2.04%,1/49),总有效3例(6.12%,3/49),差异均有统计学意义(均P<0.05);在第2周,鼓室注射组总有效率(52.38%,22/42)高于口服组(26.53%,13/49)(P<0.05),而在第4、8周,两组间痊愈、显效、有效及总有效差异均无统计学意义(均为P>0.05)。结论连续鼓室注射糖皮质激素作为突发性聋的初始治疗,可在较短时间内取得更好的听力改善。
关键词
鼓室注射;糖皮质激素;突发性聋
基金项目(Foundation):
作者
张宇;高中;刘亚军;杨皖菁;周波;李丹;肖键;王勇;
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