STAT3和SOCS3蛋白在中耳胆脂瘤中的表达及意义

The Expression of STAT3 and SOCS3 Protein in the Middle Ear Cholesteatoma

叶放蕾;李萌;李世超;王乐;赵堃;朱晓丹;张婷;

1:郑州大学第一附属医院耳鼻咽喉科

摘要
目的研究信号转导和转录激活因子3(signal transducer and activator of transcription 3,STAT3)和细胞因子信号抑制因子3(suppressor of cytokine signaling 3,SOCS3)在中耳胆脂瘤中的表达及意义。方法采用免疫组织化学法检测30例中耳胆脂瘤标本与20例正常外耳道皮肤中STAT3及SOCS3蛋白的表达。结果STAT3蛋白阳性表达定位于胞浆和胞核,其在中耳胆脂瘤上皮中阳性表达率为76.7%(23/30),高于正常外耳道皮肤组的25.0%(5/20),差异有统计学意义(P<0.05);SOCS3蛋白阳性表达主要定位于胞浆,其在中耳胆脂瘤上皮的阳性表达率为33.3%(10/30),低于正常外耳道皮肤组的65.0%(13/20),差异有统计学意义(P<0.05);在30例中耳胆脂瘤上皮组织中,STAT3与SOCS3蛋白的表达呈负相关(r=-0.476,P=0.008,P<0.05)。结论STAT3和SOCS3蛋白在中耳胆脂瘤中的异常表达可能与中耳胆脂瘤上皮细胞的过度增殖和凋亡抑制相关,进而参与了胆脂瘤的发生发展。
关键词
信号转导和转录激活因子3;细胞因子信号抑制因子3;胆脂瘤;中耳
基金项目(Foundation):
作者
叶放蕾;李萌;李世超;王乐;赵堃;朱晓丹;张婷;
参考文献

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