STAT3和SOCS3蛋白在中耳胆脂瘤中的表达及意义
The Expression of STAT3 and SOCS3 Protein in the Middle Ear Cholesteatoma
叶放蕾;李萌;李世超;王乐;赵堃;朱晓丹;张婷;
1:郑州大学第一附属医院耳鼻咽喉科
1 Tamiya T,Kashiwagi I,Takahashi R,et al.Suppressors of cytokine signaling(SOCS)proteins and JAK/STAT pathways:regulation of T-cell inflammation by SOCS1 and SOCS3[J].Arterioscler Thromb Vasc Biol,2011,31:980.
2 Martha LS,Abbie L,Lisa MH,et al.Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs:The breast cancer health disparities study[J].Breast Cancer Res Treat,2014,147:145.
3 潘松林,龚树生.中耳胆脂瘤发病机制研究进展[J].听力学及言语疾病杂志,2008,16:338.
4 杨宁,蒋立新.凋亡抑制蛋白Livin及Survivin在中耳胆脂瘤上皮的表达及意义[J].听力学及言语疾病杂志,2011,19:356.
5 Park HR,Min SK,Min K,et al.Increased expression of p63and survivin in cholesteatomas[J].Acta Otolaryngol,2009,129:268.
6 Teramo A,Gattazzo C,Passeri F,et al.Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia[J].Blood,2013,121:3843.
7 Kiu H,Nicholson SE.Biology and significance of the JAK/STAT signalling pathways[J].Growth Factors,2012,30:88.
8 Friedland DR,Eernisse R,Erbe C,et al.Cholesteatoma growth and proliferation:posttranscriptional regulation by microRNA-21[J].Otol Neurotol,2009,30:998.
9 Croker BA,Kiu H,Nicholson SE.SOCS regulation of the JAK/STAT signaling pathway[J].Semin Cell Dev Biol,2008,19:414.
10 Krebs DL,Hilton DJ.SOCS proteins:negative regulators of cytokine signaling[J].Stem Cells,2001,19:378.
11 Linossi EM,Nicholson SE.Kinase inhibition,competitive binding and proteasomal degradation:resolving the molecular function of the suppressor of cytokine signaling(SOCS)proteins[J].Immunol Rev,2015,266:123.
12 Niwa Y,Kanda H,Shinkauchi Y,et al.Methylation silencing of SOCS3promotes cell growth and migration by enhancing JAK/STAT and FAK signaling in human hepatocellular carcinoma[J].Oncogene,2005,24:6406.
13 Xiong H,Chen ZF,Liang QC,et al.Inhibition of DNA methyltransferase induces G2cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5signalling[J].J Cell Mol Med,2009,13:3668.