老年性聋易感个体血清差异蛋白的筛选
The Screening of the Changes of Peripheral Serum Protein Expression in Individuals with Age-related Hearing Loss
姜春丽;张延平;刘金伟;于丽玫;张晨彬;
1:解放军第309医院耳鼻咽喉科
2:北京市聋儿康复中心
3:第四军医大学





1于丽玫,于飞.遗传性聋病相关诊断技术及其意义[J].中国听力语言康复科学杂志,2007(3):10.
2 Coling DE,Yu KC,Somand D,et al.Effect of SOD1overexpression on age-and noise-related hearing loss[J].Free Radic Biol Med,2003,34:873.
3 Fransen,E,Bonneux,S,Corneveaux JJ,et al.Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment[J].Eur J Hum Genet,2015,23:110.
4 Fransen E,Van Laer L,Lemkens N,et al.A novel Z-scorebased method to analyze candidate genes for age-related hearing impairment[J].Ear Hear,2004,25:133.
5 Friedman RA,Van Laer L,Huentelman MJ,et al.GRM7variants confer susceptibility to age-related hearing impairment[J].Hum Mol Genet,2009,18:785.
6 Zhu Y,Zhao J,Feng B,et al.Mutations in the mitochondrial12SrRNA gene in elderly Chinese people[J].Acta Otolaryngol,2015,135:26.
7黄欣,徐雅莉,彭理,等.利用基质辅助激光解析电离飞行时间质谱联合磁珠技术寻找乳腺癌血清蛋白标志物[J].中华乳腺病杂志,2012,6:125.
8 Soltys SG,Le QT,Shi G,et al.The use of plasma surfaceenhanced laser desorption/ionization time-of-flight mass spectrometry proteomic patterns for detection of head and neck squamous cell cancers[J].Clin Cancer Res,2004,10:4806.
9马俊,缪蓉,鲁建军,等.双向电泳联合MALDI-TOF-MS技术在筛选食管癌铂类耐药患者中的应用研究[J].现代生物医学进展,2015,15:6107.
10 Honda K,Hayashida Y,Umaki T,et al.Possible detection of pancreatic cancer by plasma protein profiling[J].Cancer Res,2005,65:10613.
11刘红彦,乔玉环,荆建红,等.MALDI-TOF-MS检测宫颈浸润癌血清中蛋白质谱的变化[J].中国肿瘤临床,2009,36:694.
12廖华,杨琨,华清泉,等.强脉冲噪声暴露后大鼠听皮层蛋白质差异表达的研究[J].中华耳鼻咽喉头颈外科杂志,2011,46:839.
13 Kazemizadeh Gol MA,Lund TC,Levine SC,et al.Quantitative proteomics of vestibular schwannoma cerebrospinal fluid:apilot study[J].Otolaryngol Head Neck Surg,2016,Mar 1(Epublish ahead of print).
14 Maeda Y,Fukushima K,Kariya S,et al.Dexamethasone regulates cochlear expression of deafness-associated proteins myelin protein zero and heat shock protein 70,as revealed by iTRAQ proteomics[J].Otol Neurotol,2015,36:1255.