特异性损伤内耳螺旋神经元小鼠模型的建立
An Animal Model of Specific Damage to Spiral Ganglion Neurons in the Inner Ear
张志坚;管红霞;杨琨;肖伯奎;廖华;江洋;周涛;华清泉;
1:武汉大学人民医院耳鼻咽喉头颈外科





1 Géléoc GS,Holt JR.Sound strategies for hearing restoration[J].Science,2014,344:1241062.
2 Crouch JJ,Schulte BA.Expression of plasma membrane CaATPase in the adult and developing gerbil cochlea[J].Hear Res,1995,92:112.
3 Konishi T,Mendelsohn M.Effect of Ouabain on cochlear potentials andendolymph composition in guinea pigs[J].Acta Otolaryngol,1970,69:192.
4 Schmiedt RA,Okamura HO,Lang H,et al.Ouabain application to the round window of the gerbil cochlea:a model of auditory neuropathy and apoptosis[J].J Assoc Res Otolaryngol,2002,3:223.
5 Lang H,Li M,Kilpatrick LA,et al.Sox2up-regulation and glial cell proliferation following degeneration of spiral ganglion neurons in the adult mouse inner ear[J].J Assoc Res Otolaryngol,2011,12:151.
6 Guillery RW.On counting and counting errors[J].J Comp Neurol 2002,447:1.
7 Incesulu A,Nadol JB Jr.Correlation of acoustic threshold measures and spiral ganglion cell survival in severe to profound sensorineural hearing loss:implications for cochlear implantation[J].Ann Otol Rhinol Laryngol,1998,107:906.
8 Shi F,Edge AS.Prospects for replacement of auditory neurons by stem cells[J].Hear Res,2013,297:106.
9 Lang H,Schulte BA,Schmiedt RA.Ouabain induces apoptotic cell death in type I spiral ganglion neurons,but not type II neurons[J].J Assoc Res Otolaryngol,2005,6:63.
10 屈涓,黄华,王洁,等.哇巴因对大鼠耳蜗螺旋神经节细胞的损伤[J].中华耳鼻咽喉头颈外科杂志,2012,11:11.
11 Fu Y,Ding D,Jiang H,et al.Ouabain-induced cochlear degeneration in rat[J].Neurotox Res,2012,22:158.
12 张雪茹,杨仕明,李登科,等.不同浓度Ouabain对贵州小型猪内耳形态及听力的影响[J].中华耳科学杂志,2013,2:279.