首页 > 过刊浏览 > 文章详情

后天性感音神经性聋患者听觉中枢磁共振弥散张量成像研究

Diffusion Tensor Imaging Study of Central Auditory Pathway in Patients with Acquired Sensorineural Hearing Loss

祝康;何莹;侯瑾;闫静;郑国玺;许珉;白芝兰;

1:西安交通大学医学院第二附属医院耳鼻咽喉头颈外科

2:西安交通大学医学院第二附属医院影像科

在线阅读

摘要

目的探讨后天性感音神经性聋(sensorineural hearing loss,SNHL)及其病程对听觉中枢白质的影响。方法选后天性SNHL患者30例,根据发病时间分为突发性聋组15例和病程2年以上的SNHL组15例;并选择15例同期行MRI检查的听力正常的其它患者为对照组;运用磁共振弥散张量成像(diffusion tensor imaging,DTI)技术观察各组受试者听觉中枢下丘和外侧丘系的弥散相关参数,包括:部分各向异性(factional anisotropy,FA)值、径向弥散(radial diffusivity,RD)、轴向弥散(axial diffusivity,AD)及平均弥散(mean diffusivity,MD)。结果突聋组、病程2年以上的SNHL组及对照组双侧下丘FA值大小依次为SNHL组<对照组<突聋组(P<0.05),对照组和突聋组与2年以上SNHL组间差异均有统计学意义(P<0.05);外侧丘系右侧RD值大小依次为突聋组<对照组<0.05),右侧MD值大小依次为对照组<突聋组<0.05)。三组下丘及外侧丘系AD值差异无统计学意义(均P>0.05)。结论突聋患者的听觉中枢未发生明显异常的改变,而病程大于2年以上的后天性SNHL患者听觉中枢神经纤维束明显受到破坏,提示感音神经性听觉损失患者的病程长短对听觉传导通路的结构变化有影响。

关键词

后天性感音神经性聋;磁共振弥散张量成像;听觉传导通路

基金项目(Foundation):

国家自然科学基金(81271068);; 陕西省科技攻关项目(2012K14-02-01);; 西安交大第二附属医院科研青年基金项目(YJ(QN)200913);; 教育部博士点基金(20120201110060)资助

作者

祝康;何莹;侯瑾;闫静;郑国玺;许珉;白芝兰;

参考文献

1 Le Bihan D,Mangin JF,Poupon C,et al.Diffusion tensor imaging:concepts and applications[J].J Magn Reson Imaging,2001,13:534.

2 Kolbe S,Chapman C,Nguyen T,et al.Optic nerve diffusion changes and atrophy jointly predict visual dysfunction after optic neuritis[J].Neuroimage,2009,45:679.

3 Schoth F,Burgel U,Dorsch R,et al.Diffusion tensor imaging in acquired blind humans[J].Neurosci Lett,2006,398:178.

4 Chang Y,Lee SH,Lee YJ,et al.Auditory neural pathway evaluation on sensorineural hearing loss using diffusion tensor imaging[J].Neuroreport,2004,15:1699.

5 Lin YC,Wang JJ,Wu CM,et al.Diffusion tensor imaging of the auditory pathway in sensorineural hearing loss:change in radial diffusivity and diffusion anisotropy[J].J Magn Res Imaging,2008,28:598.

6 Wu CM,Ng SH,Wang JJ,et al.Diffusion tensor imaging of the subcortical auditory tract in subjects with congenital cochlear nerve deficiency[J].AJNR,2009,30:1773.

7 Shimony JS,Mckinstry RC,Akbudak E.Quantitative diffusion tensor anisotropy brain MR imaging:normative human data and anatomic analysis[J].Radiology,1999,212:770.

8 Song SK,Sun SW,Ramsbottom MJ,et al.Dysmyelination revealed through MRI as increased radial(but unchanged axial)diffusion of water[J].Neuroimage,2002,17:1429.

9 Toh CH,Wong AM,Wei KC,et al.Peritumoral edema of meningiomas and metastatic brain tumors:differences in diffusion characteristics evaluated with diffusion-tensor MR imaging[J].Neuroradiology,2007,49:489.

10 Thomalla G,Glauche V,Koch MA,et al.Diffusion tensor imaging detects early Wallerian degeneration of the pyramidal tract after ischemic stroke[J].Neuroimage,2004,22:1767.

11 D'Arceuil H,de Crespigny A.The effects of brain tissue decompo-sition on diffusion tensor imaging and tractography[J].Neuroimage,2007,36:64.

12 Arfanakis K,Haughton VM,Carew JD,et al.Diffusion tensor MR imaging in diffuse axonal injury[J].AJNR,2002,23:794.

13 Moon WJ,Na DG,Kim SS,et al.Diffusion abnormality of deep gray matter in external capsular hemorrhage[J].AJNR,2005,26:229.

14 熊科亮,肖新兰,龚良庚.突发性耳聋患者磁共振下内耳与听觉中枢血供的研究[J].江西医学院学报,2007,47::68.

本文信息

PDF(106K)

本文关键词相关文章

后天性感音神经性聋磁共振弥散张量成像听觉传导通路

本文作者相关文章

祝康何莹侯瑾闫静郑国玺许珉白芝兰