维生素C与过氧化氢对老年豚鼠耳蜗外毛细胞大电导钙激活钾通道电流的影响
Effects of Vitamin C and Hydrogen Dioxide on the Electric Current of Large-conductance Calcium-activated Potassium Channels in Isolated Outer Hair Cells of Old Guinea Pigs' Cochlears
赖丹;黄非;覃纲;
1:泸州医学院附属医院耳鼻咽喉-头颈外科
2:宜宾市第一人民耳鼻咽喉科
摘要关键词基金项目(Foundation):作者参考文献1 Atkinson Ns,Robertson GA,Ganetzky B.A component of calcium-activated potassium channels encoded by the Drosophila slolocus[J].Science,l991,53:551.
2 Oliver D,Knipper M,Derst C.Resting potential and submembrane calcium concentration of inner hair cells in the isolated mouse cochlea are set by KCNQ-type potassium channels[J].J Neurosci,2003,23:2141.
3 Catterall WA.Strueture and regulation of voltage-gated Ca2+channels[J].Annu Rev Cell Dev Bio1,2000,16:521.
4 Cox DH,Aldrich RW.Role of the beta1subunit in largeconductance Ca2+-activated K+channel gating energetics.Mechanisms of enhanced Ca(2+)sensitivity[J].J Gen Physiol,2000,116:411.
5 Fettiplace R,Fuchs PA.Mechanisms of hair cell tuning[J].Annu Rev Physiol,1999,61:809.
6 Ramanathan K,Fuchs PA.Modeling hair cell tuning by expression gradients of potassium channel beta subunits[J].Biophys J,2002,82(1Pt 1):64.
7 Langer P,Gründer S,Rüsch A.Expression of Ca2+-activated BK channel mRNA and its splice variants in the rat cochlea[J].J Comp Neurol,2003,455:198.
8 陈炳卿,主编.营养与食品卫生学[M].第四版.北京人民卫生出版社,2002.63~66,115~116,130.
9 顾景范,杜寿玢,查良锭,主编.现代临床营养学[M].北京科学出版社,2003.120~122,139,145,94~104,275~278,631.
10 Wang ZW,Nara M,Wang YX,et al.Redox regulation of large conductance Ca2+-activated K+channels in smooth muscle cells[J].J Gen Physiol,1997,110:35.
11 Tang XD,Daggett H,Hanner M,et al.Oxidative regulation of large conductance calcium-activated potassium channels[J].J Gen Physiol,2001,117:253.