6岁以内孤独症儿童听性脑干反应特征分析

An Analysis of Auditory Brainstem Response in Autistic Children of 6 Years or Younger

吴学文;刘明宇;王风君;陆小净;崔湘凝;陈红胜;冯永;

1:中南大学湘雅医院耳鼻咽喉头颈外科

摘要

目的探讨6岁以内孤独症儿童听性脑干反应(ABR)特征,评估孤独症儿童的听功能。方法回顾性分析6岁以内听力正常儿童(98例)及孤独症儿童(22例)的ABR测试结果,根据年龄将所有研究对象分为12岁组、2<2岁组、2<3岁组、3<3岁组、3<6岁组,对各组儿童的ABR反应阈、各波潜伏期及波间期进行统计学分析。结果 16岁组,对各组儿童的ABR反应阈、各波潜伏期及波间期进行统计学分析。结果 12岁、2<2岁、2<3岁及3<3岁及3<6岁组正常听力儿童的ABR反应阈平均值分别为15.64±5.02、14.73±4.85及15.57±5.62dB nHL,孤独症儿童的ABR反应阈平均值分别为17.50±5.35、17.81±6.58及17.25±6.97dB nHL,各年龄组正常听力儿童与孤独症儿童之间ABR平均反应阈值差异无统计学意义(P>0.05)。在80dB nHL短声刺激下,各年龄段孤独症儿童的ABR各波潜伏期或波间期平均值与正常听力儿童比较,差异均无统计学意义(P>0.05)。但是,22例孤独症儿童中,8例(36.36%,8/22)11耳(25.00%,11/44)出现ABR波潜伏期或波间期延长,其中波Ⅰ、Ⅲ、Ⅴ潜伏期及Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ波间期延长出现的几率分别为4.55%(2/44)、6.82%(3/44)、13.64%(6/44)、18.18%(8/44)、6.83%(3/44)及15.91%(7/44)。结论部分孤独症儿童存在不同程度的ABR异常,且表现形式多样,以Ⅰ-Ⅲ波间期延长最常见。

关键词

孤独症;听性脑干反应;儿童

基金项目(Foundation):

国家自然科学青年科学基金项目(81300819);; 国家自然科学基金面上项目(81170923);; “973”国家重大科学研究计划项目(2014CB943003);; 湖南省科技计划项目院士基金(2013FJ4110)联合资助

作者

吴学文;刘明宇;王风君;陆小净;崔湘凝;陈红胜;冯永;

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