缺氧诱导因子-1α在喉癌中的表达及意义

吴晓红;

1:浙江省德清县人民医院耳鼻咽喉科

摘要
目的研究缺氧诱导因子-1α(hypoxia inducible factor-1α,HIF-1α)在喉癌中的表达及意义。方法用免疫组织化学方法检测40例喉癌患者标本中缺氧诱导因子-1α的表达,并分析其与患者的年龄、吸烟、饮酒史、TNM分期、有无淋巴结转移等临床因素的相关性。结果肿瘤分期为T3、T4期及有淋巴结转移的喉癌标本中HIF-1α的阳性表达的比例分别为87.5%(14/16)和91.7%(11/12),高于T1、T2期及无淋巴结转移的患者[分别为54.2%(13/24)和57.1%(16/28)](P<0.05),而年龄、吸烟饮酒史及喉癌组织类型对HIF-1α表达无影响。结论 HIF-1α阳性高表达与喉癌的T分期和淋巴结转移可能有关。
关键词
喉癌;缺氧诱导因子-1α;TNM分期;免疫组织化学方法
基金项目(Foundation):
浙江省德清县科技局(2009Ny01)资助
作者
吴晓红;
参考文献

1范凤凤,杨华锋,唐鲁兵,等.缺氧诱导因子1α和Ki67在三阴性乳腺癌中的表达及意义[J].江苏医药,2015,3:268.

2 鲍小招,范广民,吴忠明,等.缺氧诱导因子-1α在前列腺癌中的表达及意义[J].中国现代医生,2015(07):1.

3 廖长春,范阳华,肖兵,等.缺氧诱导因子-1α与着丝粒蛋白W在人胶质瘤组织及细胞中表达的相关性[J].肿瘤,2014,11:1045.

4 许丽萍,刘春艳,陈莹.缺氧幼鼠脑组织和血清中HIF-1α的表达及意义探讨[J].中国实用神经疾病杂志,2013,23:61.

5 Yu L,Liu Y,Cui Y.Expression of hypoxia inducible factor-1 alpha and its relationship to apoptosis and proliferation in human laryngeal squamous cell carcinoma[J].J Huazhong Univ Sci Technolog Med Sci,2004,24:636.

6 钱永清,施红旗.缺氧诱导因子-1α、血管内皮生长因子在胃癌中的表达及意义[J].全科医学临床与教育,2013,6:615.

7 Kyzas PA,Stefanou D,Batistatou A,et al.Hypoxia-induced tumour angiogenic pathway in head and neck cancer:an in vivo study[J].Cancer Lett,2005,225:297.

8 Beasley NJ,Leek R,Alam M,et al.Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer:relationship to tumor biology and treatment outcome in surgically resected patients[J].Cancer Res,2002,62:2493.

9 韩丽华,苏秋香,孙佩杰,等.缺氧诱导因子-1α及P53蛋白在前列腺增生和癌变组织中的表达及对判断预后的意义[J].沈阳医学院学报,2013,4:202.

10 Schrijvers ML,van der Laan BF,de Bock GH,et al.Overexpression of intrinsic hypoxia markers HIF1αand CA-IX predict for local recurrence in stage T1-T2glottic laryngeal carcinoma treated with radiotherapy[J].Int J Radiat Oncol Biol Phys,2008,72:161.

11 Patel SG,Shah JP.TNM staging of cancers of the head and neck:striving for uniformity among diversity[J].CA Cancer J Clin,2005,55:242.

12 Cao D,Hou M,Guan YS,et al.Expression of HIF-1alpha and VEGF in colorectal cancer:association with clinical outcomes and prognostic implications[J].BMC Cancer,2009,9:432.

13 Fillies T,Werkmeister R,van Diest PJ,et al.HIF1-alpha overexpression indicates a good prognosis in early stage squamous cell carcinomas of the oral floor[J].BMC Cancer,2005,5:84.

14 Reynolds TY,Rockwell S,Glazer PM.Genetic instability induced by the tumour microenvironment[J].Cancer Res,1996,56:5754.

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