腺病毒介导的白细胞介素-10治疗自身免疫性内耳病的实验研究
Adenovirus-Mediated IL-10 Gene for the Treatment of Autoimmune Inner Ear Disease——an Experimental Study
蔡文君;谭长强;
1:东南大学附属中大医院耳鼻咽喉头颈外科
2:南京市鼓楼医院耳鼻咽喉头颈外科
摘要关键词基金项目(Foundation):作者参考文献1黄选兆,汪吉宝,孔维佳.实用耳鼻咽喉头颈外科学[M].北京:人民卫生出版社,2008.998~1001.
2 Raphael Y,Frisancho JC,Roessler BJ.Adenoviral-mediated gene transfer into guinea pig cochlear cells in vivo[J].Neurosci Lett,1996,207:137.
3 Ishimoto S,Kawamoto K,Kanzaki S,et al.Gene transfer into supporting cells of the organ of Corti[J].Hear Res,2002,173:187.
4 Sun H,Huang A,Cao S.Current status and prospects of gene therapy for the inner ear[J].Hum Gene Ther,2011,22:1311.
5 郭维,胡吟燕,翟所强,等.腺病毒携带的LacZ基因在豚鼠耳蜗中的表达[J].听力学及言语疾病杂志,2001,9:36.
6 De Kozak Y,Thillaye-Goldenberg B,Naud MC,et al.Inhibition of experimental autoimmune uveoretinitis by systemic and subconjunctival adenovirus-mediated transfer of the viral IL-10gene[J].Clin Exp Immunol,2002,130:212.
7 Liang W,Zaruhi K,Xu QH,et al.B-cell delivered gene transfer of human S-Ag-Ig fusion protein protects from experimental autoimmune uveitis[J].Clin Immunol,2006,118:35.
8 Zhou B,Kermany MH,Cai Q,et al.Experimental autoimmune hearing loss is exacerbated in IL-10-deficient mice and reversed by IL-10gene transfer[J].Gene Therapy,2012,19:228.
9 谭长强,董伟达,陆玲.同种内耳抗原免疫孕豚鼠所产子鼠听觉损伤程度与母鼠特异性免疫反应水平相关性研究[J].东南大学学报(医学版),2007,26:397.
10 杨湘宁,钟启明.同种内耳抗原免疫致豚鼠感音神经性聋的实验研究[J].中华耳鼻咽喉科杂志,1992,27:325.
11 谭长强,钟启明,曹银成,等.在自身免疫性感音神经性聋发病机理中内淋巴囊作用的实验研究[J].耳鼻喉学报,1993,7:153.
12 Iizuka T,Kanzaki S,Mochizuki H,et al.Noninvasive in vivo delivery of transgene via adeno-associated virus into supporting cells of the neonatal mouse cochlea[J].Human Gene Therapy,2008,19:384.
13 谭长强.特异性体液转移免疫致豚鼠先天性感音神经性聋实验研究[J].东南大学学报(医学版),2007,26:327.