质子泵抑制剂与促胃肠动力药治疗咽喉反流的Meta分析

Proton Pump Inhibitor and Prokinetic Drug on the Treatment of Laryngopharyngeal Reflex Diseases:A Meta-analysis

邓智锋;许昱;周涛;屈季宁;刘昀;欧劲;石文丹;

1:武汉大学人民医院耳鼻咽喉头颈外科

摘要
目的评价质子泵抑制剂联合促胃肠动力药治疗咽喉反流的疗效和安全性。方法根据预定的纳入、排除标准,在cochrane图书馆、Embase、Elsevier、Pubmed、维普数据库(VIP)、万方数据库、中国知网(CNKI)和中国生物医学文献数据库(CBM)等中英文数据库中对应用质子泵抑制剂与促胃肠动力药治疗咽喉反流的文献进行检索,检索时限均为从建库至2012年11月。由三名评价员独立提取资料,应用Meta分析软件包Revman 5.1和GRAEDprofiler3.6对纳入的文献进行统计分析。结果共检索相关文献346篇,最终共纳入7篇符合纳入标准的文献,共614例患者,试验组及对照组各307例,试验组治疗方案为质子泵抑制剂和促胃肠动力药联合治疗,对照组为单用其中一种药。Meta分析结果显示:质子泵抑制剂和促胃肠动力药联合治疗咽喉反流患者的总体有效率高于对照组[RR=1.18,95%CI(1.10,1.28),P<0.0001];纤维喉镜检查咽喉部体征好转率高于对照组[RR=1.38,95%CI(1.16,1.65),P<0.001];发声障碍症状平均消失时间短于对照组[MD=-1.70,95%CI(-2.95,-0.45),P<0.001]。结论质子泵抑制剂联合促胃肠动力药较分别单用这两类药治疗咽喉反流的疗效更显著,但就安全性而言,尚需更多的大样本、多中心、方法科学的高质量随机对照实验来进一步论证。
关键词
质子泵抑制剂;促胃肠动力药;咽喉反流;Meta分析
基金项目(Foundation):
作者
邓智锋;许昱;周涛;屈季宁;刘昀;欧劲;石文丹;
参考文献

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