IL-18对分泌性中耳炎模型大鼠中耳IFN-γ和IL-4表达的影响
The Effects of interleukin-18 on Middle Ear Inflammation in the Rat Model of Otitis Media with Effusion
刘华;赵守琴;高占梅;范尔钟;李洁;宋扬;
1:河北医科大附属唐山市工人医院耳鼻喉科
2:首都医科大学附属北京同仁医院耳鼻咽喉头颈外科
3:北京市耳鼻咽喉科研究所基础部
4:首都医科大学附属北京复兴医院
摘要关键词基金项目(Foundation):作者参考文献1 Nguyen LH,Manoukian JJ,Sobol SE,et al.Similar allergic inflammation in the middle ear and the upper airway:evidence linking otitis media with effusion to the united airways concept[J].J Allergy Clin Immunol,2004,114:1 110.
2 Nguyen LH,Manoukian JJ,Tewfik TL,et al.Evidence of allergic inflammation in the middle ear and nasopharynx in atopic children with otitis media with effusion[J].J Otolaryngol,2004,33:345.
3 Sobol SE,Taha R,Schloss MD,et al.T(H)2cytokine expression in atopic children with otitis media with effusion[J].J Allergy Clin Immunol,2002,110:125.
4 Wright ED,Hurst D,Miotto D,et al.Increased expression of major basic protein(MBP)and interleukin-5(IL-5)in middle ear biopsy specimens from atopic patients with persistent otitis media with effusion[J].Otolaryngol Head Neck Surg,2000,123:533.
5 Stephens R,Eisenbarth SC,Chaplin DD.T helper type 1cells in asthma:friend or foe[J]?Curr Opin Allergy Clin Immunol,2002,2:31.
6 Okamura H,Tsutsui H,Kashiwamura S,et al.Interleukin-18 :a novel cytokine that augments both innate and acquired immunity[J].Adv Immunol,1998,70:281.
7 Hardy SM,Heavner SB,White DR,et al.The role of latephase allergy in the development of eustachian tube dysfunction[J].Otolaryngol Head Neck Surg,2001,125:339.
8 张惠兰,张珍祥,徐永健.白细胞介素-18对支气管哮喘小鼠气道炎症和核转录因子κB的作用[J].中华微生物和免疫学杂志,2002,22:139.
9 赵守琴,刘华,韩德民,等.变应原诱发大鼠分泌性中耳炎中耳核因子κB的表达[J].临床耳鼻咽喉头颈外科杂志,2008,16:751.
10 刘华,赵守琴,宋扬,等.大鼠分泌性中耳炎中耳Th1/Th2细胞失衡模式的研究[J].中华临床医师杂志(电子版),2011,24:7 282.
11 Pollock HW,Ebert CS,Dubin MG,et al.The role of soluble interleukin-4receptor and interleukin-5antibody in preventing late-phase allergy-induced eustachian tube dysfunction[J].Otolaryngol Head Neck Sur,2002,127:169.
12 孙荣,洪苏玲,唐新业.变态反应性中耳炎动物模型的建立及Ⅰ型变态反应与分泌性中耳炎关系的探讨[J].临床耳鼻咽喉科杂志,2005,19:170.
13 Walter DM,Wong CP,DeKruyff RH,et al.Il-18gene transfer by adenovirus p revents the development of and reverses established allergen-induced airway hyperreactivity[J].J Immunol,2001,166:6 392.
14 陈湘琦、林挺岩.白细胞介素18对豚鼠哮喘模型气道炎症作用的实验研究[J].中华医学杂志,2005,28:1 995.
15 Hofstra CL,Van Ark I,Hofman G,et al.Prevention of Th2-like cell responses by coadministration of IL-12and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness,eosinophilia,and serum IgE levels[J].J Immunol,1998,161:5 054.
16 Nakanishi K,Yoshimoto T,Tsutsui H,et al.Interleukin-18 is a unique cytokine that stimulates both Th1and Th2responses depending on its cytokine milieu[J].Cytokine Growth Factor Rev,2001,12:53.
17 Murai H,Qi H,Choudhury B,et al.Alternaria-induced release of IL-18from damaged airway epithelial cells:an NF-κB dependent mechanism of Th2differentiation[J]?PLoS One,2012,7:e30 280.
18 Dao T,Ohashi K,Kayano T,et al.Interferon-gamma-inducing factor,a novel cytokine,enhances Fas ligand-mediated cytotoxicity of murine T helper 1cells[J].Cell Immunol,1996,173:230.
19 Sugimoto T,Ishikawa Y,Yoshimoto T,et al.Interleukin 18acts on memory T helper cells type1to induce airway inflammation and hyperresponsiveness in a na?ve host mouse[J].J Exp Med,2004,199:535.
20 Verhaeghe B,Gevaert P,Holtappels G,et al.Up-regulation of IL-18in allergic rhinitis[J].Allergy,2002,57:825.
21 张明,刘立思.白细胞介素-18在变应性鼻炎中的作用[J].临床耳鼻咽喉科杂志,2004,18:257.