鼠神经生长因子治疗突发性聋的临床疗效观察

涂博;蒋立新;马玉坤;

1:暨南大学附属第一医院耳鼻咽喉头颈外科

摘要

目的观察鼠神经生长因子(mouse nerve grouth factor,mNGF)治疗突发性聋的疗效。方法将60例(60耳)突发性聋患者随机分为mNGF治疗组和常规治疗组,每组30例(30耳)。常规治疗组给予丹参川穹注射液、氢化泼尼松注射液及高压氧治疗;mNGF治疗组在常规治疗的基础上同时给予肌肉注射mNGF 18μg,每日一次,两组均连续治疗1012天。两组均于治疗前后行听性脑干反应及纯音听阈测试,比较疗效。结果 mNGF治疗组总有效率为86.67%(26/30),明显优于常规治疗组(63.33%,19/30)(P<0.05)。结论鼠神经生长因子mNGF可明显提高突发性聋的临床疗效。

关键词

突发性聋;鼠神经生长因子

基金项目(Foundation):

作者

涂博;蒋立新;马玉坤;

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突发性聋鼠神经生长因子

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涂博蒋立新马玉坤