庆大霉素耳毒性模型大鼠耳蜗凋亡诱导因子表达及阿司匹林的拮抗作用
Modification of Aspirin to Expression of AIF in Gentamicin Ototoxicity Model
陈晓栋;王烨;丁忠家;杨佳蕾;王曦;赵昱;岳波;陈福权;邱建华;
1:第四军医大学西京医院全军耳鼻咽喉-头颈外科专科中心
2:第四军医大学西京医院神经内科
摘要关键词基金项目(Foundation):作者参考文献1 Forge A,Schacht J.Aminoglycoside antibiotics[J].Audiol Neurootol,2000,5:3.
2 Schatz A,Bugie E,Waksman SA.Streptomycin,a substance exhibiting antibiotic activity against gram-positive and gram-negative bacteria.1944[J].Clin Orthop Relat Res,2005,437:3.
3 Conlon BJ,Aran JM,Erre JP,et al.Attenuation of aminoglycoside-induced cochlear damage with the metabolic antioxidant alpha-lipoic acid[J].Hear Res,1999,128:40.
4 Rybak LP,Whitworth CA.Ototoxicity:therapeutic opportunities[J].Drug Discov Today,2005,10:1 313.
5 陈阳,黄维国,查定军,等.阿司匹林预防庆大霉素耳毒性的随机对照试验[J].中华耳科学杂志,2008,6:145.
6 Sha SH,Qiu JH,Schacht J.Aspirin to prevent gentamicininduced hearing loss[J].N Engl J Med,2006,354:1 856.
7 Sevrioukova IF.Apoptosis-inducing factor:structure,function,and redox regulation[J].Antioxid Redox Signal,2011,14:2 545.
8 Lecain E,Omri B,Behar-Cohen F,et al.The role of PKCzeta in amikacin-induced apoptosis in the cochlea:prevention by aspirin[J].Apoptosis,2007,12:333.
9 蔡琴芳,蒋立新.豚鼠耳蜗基底膜硝酸银染色铺片法的改良与观察[J].听力学及言语疾病杂志,2010,18:282.
10 Zhang D,Fan Z,Han Y,et al.Apoptosis-inducing factor is involved in gentamicin-induced vestibular hair cell death[J].ORL J Otorhinolaryngol Relat Spec,2012,74:1.
11 Torres-Ruiz NM,Granados O,Meza G.Aminoglycosides:therapeutics,ototoxicity and hypersensitivity of mitochondrial genetic origin[J].Proc West Pharmacol Soc,2011,54:49.
12 陈林,王海涛,陆云刚,等.水杨酸钠诱导耳鸣的神经机制[J].中国科学技术大学学报,2008,38:987.
13 王锦玲,陈贤明,刘顺利.水杨酸钠对爆震性聋治疗作用的实验研究[J].听力学及言语疾病杂志,2001,9:1.
14 Xiao T,Zhang Y,Wang Y,et al.Activation of an apoptotic signal transduction pathway involved in the upregulation of calpain and apoptosis-inducing factor in aldosterone-induced primary cultured cardiomyocytes[J].Food Chem Toxicol,2013,53:364.
15 Op DBK,Schacht J,Van Camp G.Apoptosis in acquired and genetic hearing impairment:the programmed death of the hair cell[J].Hear Res,2011,281:18.