Ras相关区域家族1A基因在喉癌及喉角化症组织中的表达及临床意义

Immunohistochemical Expression and Clinical Implication of RASSF1A Gene in Laryngeal Squamous Cell Carcinoma and Keratosis of the Larynx

李万举;孙敬武;别远志;

1:安徽省立医院耳鼻咽喉头颈外科

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摘要

目的探讨Ras相关区域家族1A基因(Ras association domain family 1A,RASSF1A)的表达与喉癌发生发展的关系。方法收集喉角化症组织43例、喉鳞癌组织31例作为实验组,取冷冻新鲜尸头正常声带黏膜8例作为正常对照组,用免疫组织化学方法检测各组组织的RASSF1A蛋白表达情况并进行分析比较。结果正常喉黏膜、喉角化症及喉鳞状细胞癌组织中RASSF1A阳性细胞表达率分别为58.25%±8.8%、47.22%±2.25%和21.36%±10.98%,喉鳞状细胞癌组织中RASSF1A的表达强度低于喉角化症及正常喉粘膜组织,差异均有统计学意义(P<0.05),喉角化症与正常喉黏膜组织中的RASSF1A阳性表达率差异无统计学意义(P>0.05)。在IIV期喉癌组织中RASSF1A的表达强度逐渐降低,差异有统计学意义(P<0.05),而高分化、中分化及低分化癌组织中RASSF1A阳性细胞表达率比较,差异无统计学意义(P>0.05)。结论 RASSFlA表达降低可能与喉鳞状细胞癌的发生发展有关,对鉴别癌前病变与喉癌具有一定意义。

关键词

喉癌;喉角化症;Ras相关区域家族1A基因

基金项目(Foundation):

作者

李万举;孙敬武;别远志;

参考文献

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喉癌喉角化症 Ras相关区域家族1A基因

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李万举孙敬武别远志