即早基因c-Jun在顺铂诱发豚鼠耳蜗Corti器细胞凋亡中的作用
The Role of C-Jun Associated with in Cisplatin(CDDP) Apoptosis in Guinea Pig Cochlea
邢奋丽;邓毅;王林娥;曹克利;
1:南京医科大学附属南京第一医院耳鼻咽喉科
2:首都医科大学附属北京友谊医院耳鼻咽喉科
3:中国协和医科大学中国医学科学院北京协和医院耳鼻咽喉科





1 Greer JE,McGinn MJ,Povlishock JT.Diffuse traumatic ax-onal injury in the mouse induces atrophy,c-Jun activation,and axonal outgrowth in the axotomized neuronal population[J].J Neurosci,2011,31:5 089.
2赵晓鸿,陈照丽,赵守华,等.COX-2及其转录因子NFAT3和c-Fos在非小细胞肺癌中的表达及意义[J].中国肺癌杂志,2010,11:1 035.
3 Xu P,Das M,Reilly J,et al.JNK regulates FoxO-depen-dent autophagy in neurons[J].Genes Dev,2011,25:310.
4 Rybak LP.Mechanisms of cisplatin ototoxicity and progress in otoprotection[J].Curr Opin Otolaryngol Head Neck Surg,2007,15:364.
5 Ganm C,Holnmin S,Mathiesen T.Temporal profiles and cel-lular sources of three nitric oxide sythases isoforms in the brain after experimental contusion[J].Neurosurgery,2000,46:169.
6 Shalini S,Bansal MP.Co-operative effect of glutathione de-pletion and selenium induced oxidative stress on API and NFkB expression in testicular cells in vitro:insights to regulation of spermatogenesis[J].Biol Res,2007,40:307.
7许辉杰,黄魏宁.顺铂作用下沙鼠耳蜗螺旋神经节神经元和Corti器细胞的凋亡[J].中华耳鼻咽喉科杂志,2003,38:98.
8 Marek KW,Kurtz LM,Spitzer NC.c-Jun integrates calcium activity and tlx3expression to regulate neurotransmitter speci-fication[J].Nat Neurosci,2010,13:944.
9 Lefebvre P,Malgrange B,Lallemend F,et al.Mechanisms of cell death in the injured auditory system:otoprotective strate-gies[J].Audiol Neurotol,2002,7:165.
10 Martin LJ,Bergeron F,Viger RS,et al.Functional coopera-tion between GATA factors and c-Jun on the star promoter in MA-10leyclig cells[J].J Androl,2012,33:81.