γ分泌酶抑制剂DAPT对庆大霉素致大鼠耳损伤及修复过程中听力及Notch2/hes1信号通路表达的影响
Effects of DAPT on Hearing and Notch2/hes1 Signaling Pathways Expression in Gentamicin-induced Hearing Injury and Repair Process in Rat
黄飞;刘成福;王小琴;
1:湖北中医药大学中医临床学院
2:湖北省中医院肾内科





1 Wei M,Lu X.Effects ofγ-Secretase Inhibitor DAPT on cell growth in human cervical carcinoma cell line hela[J].J Liaol-ing Medical University,2010,10:390.
2 Yan H,Jiang F.Recent advances in the research ofγ-Secre-tase inhibitors[J].Progress in Chemistry,2006,3:355.
3 Takebayashi S,Yamamoto N,Yabe D,et al.Multile roles of Notch signaling in clchlear development[J].Dev Biol,2007,307:165.
4 Yamamoto N,Tanigaki K,Tsuji M,et al.Inhibition of Notch/RBP-J signaling induced hair cell formation in neonate mouse cochleas[J].J Mol Med,2006,84:37.
5 Zine A,Aubert A,Qiu J,et a1.Hesl and hes5activities are re-quired for the normal development of the hair cells in the mam-malian inner ear[J].The Journal of Neuroscience,2001,21:4712.
6 Mizutani T,Taniguehi Y,Aoki T,et al.Conservation of thebiochemical mechanisms of signal transduction among mam-mlian Notch family members[J].PNAS,2001,98:9026.
7 Kavian N,Servettaz A,et al.Targeting ADAM-17/Notch signaling abrogates the development of systemic sclerosis in a murine model.Arthritis,2010,11:3 477.
8 Livak KJ,Schmittgen TD.Analysis of relative gene expres-sion data using real-time quantitative PCR and the 2-ΔΔCT method[J].Methods,2001,25:402.
9 Chyung JH,Raper DM,Selkoe DJ.γ-Secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage[J].The Journal of Biologi-cal Chemistry,2005,280:4 383.
10 Daudet N,Ariza-McNaughtonl L,Lewis J.Notch signaling is needed to maintain,but not to initiate,the formation of prosensory patches in the chick inner ear[J].Develpment,2007,134:2 369.