内耳基因治疗的研究进展

吴学文;孙虹;

1:中南大学湘雅医院耳鼻咽喉科

2:耳鼻咽喉重大疾病研究湖南省重点实验室

摘要
<正>由于先天性异常、后天性损伤如病毒性疾病和耳毒性药物以及老年退行性变等原因,内耳疾病患者不断增多。内耳疾病主要表现为听力下降和眩晕,重者导致语言交流障碍和行动困难,是一类严重影响人类正常生活的常见难治性、致残性疾病。内耳疾病的病理以耳蜗和/或前庭感觉上皮的细胞(如毛细胞和支持细胞)及神经元不同程度受损为主,在临床上表现为各种感音神经性聋(如遗传性聋、突发性聋、噪声性聋、药物性聋、老年性聋和自身免疫性聋等)及各类前庭周围性眩晕(如梅尼埃病)等。
关键词
基金项目(Foundation):
教育部博士点基金(20110162110007);; 国家自然科学基金(81170912,30772402);; 湖南省自然科学基金(02JJY2050)联合资助
作者
吴学文;孙虹;
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