23例肌萎缩侧索硬化症患者喉肌电图的特点

The Laryngeal Electromyography Features of 23 Patients with Amyotrophic Lateral Sclerosis

谢华顺;马芙蓉;樊东升;王丽平;闫燕;郑菊阳;鹿培泉;张绍兴;

1:北京大学第三医院耳鼻咽喉头颈外科

2:北京大学第三医院神经内科

摘要
目的分析肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS)患者喉肌电图的特点。方法对23例临床确诊的肌萎缩侧索硬化症(以球部症状起病8例,以肢体症状起病15例)并伴有球部症状和/或声嘶表现的患者的右侧环甲肌、甲杓肌及环杓后肌进行喉肌电图检测,分析其结果。结果共检测了23例患者69块喉内肌的肌电图,其中10例患者共11块肌肉表现为典型的失神经支配,存在纤颤、正锐波、多相运动单位电位、巨大的再生电位等;环甲肌异常率最高,异常率为43.48%(10/23),仅1例患者表现为甲杓肌异常,环杓后肌未见异常肌电图表现;球部起病患者异常率为75.0%(6/8),肢体起病患者异常率为26.67%(4/15),前者高于后者,差异有统计学意义(P<0.05)。不同性别、是否有球部症状、是否有呛咳症状患者的喉肌电图异常率比较差异无统计学意义。结论部分ALS患者喉内肌肌电图有失神经支配表现,球部起病患者的喉肌受累率高于肢体起病患者;环甲肌受累最多。
关键词
肌萎缩侧索硬化症;运动神经元病;喉肌电图
基金项目(Foundation):
作者
谢华顺;马芙蓉;樊东升;王丽平;闫燕;郑菊阳;鹿培泉;张绍兴;
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