听觉剥夺大鼠听皮层BDNF和TrkB的表达变化
Expression of BDNF and TrkB in Rat Auditory Cortex after Bilateral Cochlear Ablation
王玉杏;徐鸥;刘砚星;黄河银;路虹;
1:河北医科大学第二医院耳鼻咽喉科
2:河北医科大学药理学教研室
摘要关键词基金项目(Foundation):作者参考文献1 Palmer CV,Nelson CT,Lindley GA 4th.The functionally and physiologically plastic adult auditory system[J].J Acoust Soc Am,1998,103:1 705.
2 Oh SH,Kim CS,Song JJ.Gene expression and plasticity in the rat auditory cortex after bilateral cochlear ablation[J].Acta Otolaryngological,2007,127:341.
3 McAllister AK.BDNF[J].Curr Biol,2002,12:R 310.
4 Zhang LI,Bao S,Merzenich MM.Disruption of primary audi-tory cortex by synchronous auditory inputs during a critical period[J].Proc Natl Acad Sci U S A,2002,99:2 309.
5 Zhang LI,Bao S,Merzenich MM.Persistent and specific in-fluences of early acoustic environments on primary auditory cortex[J].Nat Neurosci,2001,4:1 123.
6张萌,陈晓巍,田永胜.耳蜗毁损后小鼠听觉中枢的退行性改变[J].中华耳鼻咽喉头颈外科杂志,2009,44:571.
7 Pandya CD,Kutiyanawalla A,Pillai A.BDNF-TrkB signaling and neuroprotection in schizophrenia[J].Asian J Psychiatr,2013,6:22.
8 Nakahara H,Zhang LI,Merzenich MM.Specialization of primary auditory cortex processing by sound exposure in the"critical peri-od"[J].Proc Natl Acad Sci U S A,2004,101:7 170.
9 Tan J,Widjaja S,Xu J,et al.Cochlear implants stimulate ac-tivity-dependent CREB pathway in deaf auditory cortex:im-plications for molecular plasticity induced by neural prosthetic devices[J].Cerebral Cortex,2008,18:1 799.
10时海波,殷善开,冯艳梅,等.听觉剥夺延缓大鼠上外橄榄核神经元抑制性突触的发育[J].上海交通大学学报(医学版),2007,9:1 049.
11 Ohira K,Funatsu N,Homma KJ,et al.Truncated TrkB-T1regulates the morphology of neocortical layer I astrocytes in adult rat brain slices[J].Eur J Neurosci,2007,25:406.
12 Wong J,Garner B.Evidence that truncated TrkB isoform,TrkB-Shc can regulate phosphorylated TrkB protein levels[J].Biochem Biophys Res Commun,2012,420:331.
13 Svirsky MA,Teoh SW,Neuburger H.Development of lan-guage and speech perception in congenitally,profoundly deaf children as a function of age at cochlear implantation[J].Au-diol Neurootol,2004,9:224.
14 Hayes H,Geers AE,Treiman R,et al.Receptive vocabula-ry development in deaf children with cochlear implants:a-chievement in an intensive auditory-oral educational setting[J].Ear Hear,2009,30:128.