小剂量安定类药物治疗慢性耳鸣的安全性

石勇兵;

1:美国俄勒冈医科大学(Oregon Health & Science University

2:OHSU)耳鼻咽喉科

摘要
目的探讨安定类药物治疗慢性耳鸣的作用及安全性。方法 2010年9月2011年3月47例慢性耳鸣患者接受安定类药物治疗,对其中26例患者进行电话随访,随访内容包括询问所使用的具体药物品种、剂量、使用的时间长短、副作用、疗效以及是否停止使用该药物和停用的原因。结果本组患者使用小剂量安定类药物多在5个月以上,26例中,14例(53.85%)有一过性或容易耐受的轻微副作用,包括困顿、疲倦、头晕、恶梦、食欲增加、头痛、言语不流畅等;6例(23.08%)在两次使用药物之间或忘记使用药物时有耳鸣等症状反弹;20例(76.92%)感受到了药物的不同疗效;9例(34.62%)在接受随访时已经停药,但其中仅有2例停用的原因是缘于难以耐受药物的副作用;17例仍在继续使用安定类药物的患者中10例均使用低于医嘱指定的剂量。随访中没有发现滥用药物的现象。结论低剂量安定类药物对慢性耳鸣有一定的疗效,但部分患者可能产生短暂或较容易耐受的轻微副作用,长期使用时少部分患者可能产生轻度的药物依赖,多数患者会自主寻求减低药物用量。
关键词
耳鸣;安定
基金项目(Foundation):
作者
石勇兵;
参考文献

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