1 Beck J,Lenart B,Kintner DB,et al.Na-K-Cl cotransport-er contributes to glutamate-mediated excitotoxicity[J].J Neurosci,2003,23:5 061.

2 Paoletti P,Neyton J.NMDA receptor subunits:function and pharmacology[J].Curr Opin Pharmacol,2007,7:39.

3 Wang W,Ye SD,Zhou KQ,et al.High doses of salicylate and aspirin are inhibitory on acid-sensing ion channels and protective against acidosis-induced neuronal injury in the rat cortical neuron[J].J Neurosci Res,2011,90:267.

4 Wang F,Zhai H,Huang L,et al.Aspirin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity in prima-ry midbrain cultures[J].J Mol Neurosci,2011,46:153.

5 Crisanti P,Laplace O,Lecain E,et al.The role of PKCzeta in NMDA-induced retinal ganglion cell death:prevention by as-pirin[J].Apoptosis,2006,11:983.

6 Katz KD,Curry SC,Brooks DE,et al.The effect of cyclospo-rine A on survival time in salicylate-poisoned rats[J].J Emerg Med,2004,26:151.

7 Kiss K,Kiss J,Rudolf E,et al.Sodium salicylate inhibits NF-kappaB and induces apoptosis in PC12cells[J].J Biochem Biophys Methods,2004,61:229.

8 Jung HH,Kim HJ,Im GJ,et al.Differential protein expres-sion profiles in salicylate ototoxicity of the mouse cochlea[J].Hear Res,2009,255:121.

9 Gong N,Zhang M,Zhang XB,et al.The aspirin metabolite salicylate enhances neuronal excitation in rat hippocampal CA1 area through reducing GABA ergic inhibition[J].Neurophar-macology,2008,54:454.

10 Wang J,Tymczyszyn N,Yu Z,et al.Overexpression of X-linked inhibitor of apoptosis protein protects against noise-induced hearing loss in mice[J].Gene Ther,2011,18:560.

11 Tabuchi K,Nishimura B,Tanaka S,et al.Ischemia-reper-fusion injury of the cochlea:pharmacological strategies for cochlear protection and implications of glutamate and reactive oxygen species[J].Curr Neuropharmacol,2010,8:128.

12 Steinbach S,Lutz J.Glutamate induces apoptosis in cultured spiral ganglion explants[J].Biochem Biophys Res Commun,2007,357:14.

13 Guitton MJ,Caston J,Ruel J,et al.Salicylate induces tinni-tus through activation of cochlear NMDA receptors[J].J Neurosci,2003,23:3 944.

14 Wang HT,Luo B,Zhou KQ,et al.Sodium salicylate re-duces inhibitory postsynaptic currents in neurons of rat audi-tory cortex[J].Hear Res,2006,215:77.

15 Basta D,Goetze R,Ernst A.Effects of salicylate application on the spontaneous activity in brain slices of the mouse co-chlear nucleus,medial geniculate body and primary auditory cortex[J].Hear Res,2008,240:42.

16 de Almeida-Silva I,de Oliveira JA,Rossato M,et al.Spontaneous reversibility of damage to outer hair cells after sodium salicylate induced ototoxicity[J].J Laryngol Otol,2011,125:786.

17 Deng A,Lu J,Sun W.Temporal processing in inferior collicu-lus and auditory cortex affected by high doses of salicylate[J].Brain Res,2010,1 344:96.

18 Wei L,Ding D,Salvi R.Salicylate-induced degeneration of cochlea spiral ganglion neurons-apoptosis signaling[J].Neuroscience,2010,168:288.

19 Kimitsuki T,Kakazu Y,Matsumoto N,et al.Salicylate-induced morphological changes of isolated inner hair cells and outer hair cells from guinea-pig cochlea[J].Auris Nasus Larynx,2009,36:152.

20 Chen GD,Kermany MH,D'Elia A,et al.Too much of a good thing:long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity[J].Hear Res,2010,265:63.

21 Feng H,Yin SH,Tang AZ,et al.Caspase-3activation in the guinea pig cochlea exposed to salicylate[J].Neurosci Lett,2010,479:34.

22 Feng H,Yin SH,Tang AZ,et al.Salicylate initiates apop-tosis in the spiral ganglion neuron of guinea pig cochlea by ac-tivating caspase-3[J].Neurochem Res,2011,36:1 108.

23 Schenone S,Brullo C,Musumeci F,et al.Src kinase inhibi-tors:an update on patented compounds[J].Curr Med Chem,2011,18:5 061.

24 Kemp PJ,Telezhkin V,Wilkinson WJ,et al.Enzyme-linked oxygen sensing by potassium channels[J].Ann N Y Acad Sci,2009(1 177):112.

25 Gonzalez-Gutierrez G,Telezhkin V,Wilkinson WJ,et al.The Src homology 3domain of the beta-subunit of voltage-gated calcium channels promotes endocytosis via dynamin in-teraction[J].J Biol Chem,2007,282:2 156.

26 Kim NH,Park KS,Cha SK,et al.Src family kinase potenti-ates the activity of nicotinic acetylcholine receptor in rat auto-nomic ganglion innervating urinary bladder[J].Neurosci Lett,2011,494:190.

27 Xu J,Liu Y,Zhang GY.Neuroprotection of GluR5-contai-ning kainate receptor activation against ischemic brain injury through decreasing tyrosine phosphorylation of N-methyl-D-aspartate receptors mediated by Src kinase[J].J Biol Chem,2008,283:29 355.

28 Meissirel C,Ruiz de Almodovar C,Knevels E,et al.VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation[J].Proc Natl Acad Sci USA,2011,108:13 782.

29 Li S,Cao J,Yang X,et al.NR2Bphosphorylation at tyro-sine 1472in spinal dorsal horn contributed to N-methyl-D-aspartate-induced pain hypersensitivity in mice[J].J Neurosci Res,2011,89:1 869.

30 Pascoli V,Besnard A,HervéD,et al.Cyclic adenosine mono-phosphate-independent tyrosine phosphorylation of NR2Bmedi-ates cocaine-induced extracellular signal-regulated kinase activation[J].Biol Psychiatry,2011,69:218.

31 Hossain MI,Kamaruddin MA,Cheng HC.Aberrant regula-tion and function of Src-family tyrosine kinases-their po-tential contributions to glutamate-induced neurotoxicity[J].Clin Exp Pharmacol Physiol,2011.http://www.ncbi.nlm.nih.gov/pubmed.

32 Li HB,Jackson MF,Yang K,et al.Plasticity of synaptic GluN receptors is required for the Src-dependent induction of long-term potentiation at CA3-CA1synapses[J].Hip-pocampus,2011,21:1 053.

33 Le HT,Maksumova L,Wang J,et al.Reduced NMDA receptor tyrosine phosphorylation in PTP alpha-deficient mouse synapto-somes is accompanied by inhibition of four src family kinases and Pyk2:an upstream role for PTPalpha in NMDA receptor reg-ulation[J].J Neurochem,2006,98:1 798.

34 Metere A,Mallozzi C,Minetti M,et al.Quinolinic acid modulates the activity of src family kinases in rat striatum:in vivo and in vitro studies[J].J Neurochem,2006,97:1 327.

35 Wang Z,Brecher P.Salicylate inhibits phosphorylation of the nonreceptor tyrosine kinases,proline-rich tyrosine kinase 2 and c-Src[J].Hypertension,2001,37:148.

36 Perez GM,Melo M,Keegan AD,et al.Aspirin and salicy-lates inhibit the IL-4-and IL-13-induced activation of STAT6[J].J Immunol,2002,168:1 428.