语后聋患者人工耳蜗植入后短期内失匹配负波的表现

Performance of Mismatch Negativity in Postlingually-deafened Patients after Cochlear Implant

陈涛;梁茂金;郑亿庆;李湘辉;黄秋红;张雪媛;张志钢;陈穗俊;

1:中山大学孙逸仙纪念医院耳鼻咽喉科

摘要

目的了解语后聋人工耳蜗植入者听觉中枢重塑过程中不同时期失匹配负波(mismatch negativity,MMN)的表现,探讨利用MMN评估其听觉中枢重塑的可能性。方法对6例语后聋人工耳蜗植入(CI)者(CI组)于开机时、开机后1、3及6个月分别行MMN检查,记录其MMN潜伏期及波幅,并与6例正常人(对照组)的MMN潜伏期及波幅相比较。结果 CI组3例(50%)患者在开机时引出MMN,6例(100%)开机后1、3、6个月均引出MMN,对照组6例(100%)正常人均引出MMN。CI组开机时、开机后1、3、6个月MMN的潜伏期分别为230.67±15.50、197±53.72、136.00±31.71、132.17±9.41ms;波幅分别为-2.53±3.09、-1.60±1.15、-1.83±0.96、-1.31±1.38mV;对照组MMN的潜伏期为142.0±23.10ms,波幅为-2.17±1.17mV。CI组开机时、开机后1个月MMN的潜伏期均较对照组延长,差异有统计学意义(P=0.001和P=0.044);开机后3、6个月MMN潜伏期与对照组比较差异无统计学意义(P=0.716和P=0.357)。CI患者在开机时、开机后1、3个月,MMN潜伏期逐渐缩短,差异有统计学意义(P<0.001),开机后3、6个月MMN潜伏期比较,差异无统计学意义(P=0.778)。开机时至开机后6个月,MMN波幅变化无明显规律。结论语后聋人工耳蜗植入者开机后3个月内其MMN潜伏期逐渐缩短,开机后3个月时其MMN波形分化达正常人水平,但波幅变化无明显规律。

关键词

语后聋;人工耳蜗植入;失匹配负波

基金项目(Foundation):

作者

陈涛;梁茂金;郑亿庆;李湘辉;黄秋红;张雪媛;张志钢;陈穗俊;

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语后聋人工耳蜗植入失匹配负波

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陈涛梁茂金郑亿庆李湘辉黄秋红张雪媛张志钢陈穗俊