1Kendall K.Presbyphonia:Areview[J].Current Opinion in Otolaryngology&Head and Neck Surgery,2007,15:137.

2Thomas LB,Harrison AL,Stemple JC.Aging thyroarytenoid and li mb skeletal muscle:Lessons in contrast[J].J Voice,2008,22:430.

3Kandogan T,Olgun L,Gultekin G.Causes of dysphonia in patient above60years of age[J].Kulak Burun Bogaz Ihtis Derg,2003,11:139.

4Costa HO,Matias C.Vocal i mpact on quality of life of elderly female subjects[J].Rev Bras Otorrinologingol,2005,71:172.

5Verdonck-de LeeuwI M,Mahieu HF.Vocal aging and the i mpact on daily life:Alongitudinal study[J].J Voice,2004,18:193.

6Pontes P,Brasolotto A,Behlau M.Glottic characteristics and voice complaint in the elderly[J].J Voice,2005,19:84.

7Bloch I,Behrman A.Quantitative analysis of videostrobscopic i mages in presbylarynges[J].The Laryngoscope,2001,111:2022.

8Pontes P,Yamasaki R,Behlau M.Morphological and func-tional aspect of the senile larynx[J].Folia Phoniatr Logop,2006,58:151.

9Baken RJ.The aged voice:A new hypothesis[J].J Voice,2005,19:317.

10Torre P III,Barlow JA.Age-related changes in acoustic characterics of adult speech[J].Journal of Communication Disorders,2009.

11Gorham-Rowan MM,Laures-Gore J.Acoustic-perceptu-al correlates of voice quality in elderly men and womens[J].Journal of Communication Disorders,2006,39:171.

12Nishio M,Nii mi S.Changes in speaking fundamental fre-quency characteristics with aging[J].Folia Phoniatr Logop,2008,60:120.

13万萍,黄昭鸣.年龄和性别因素对老年嗓音的影响[J].临床耳鼻咽喉头颈外科杂志,2007,21:929.

14Reubold U,Harrington J,Kleber F.Vocal aging effects on F0and the first formant:A longitudinal analysis in adult speakers[J].Speech Communication,2010.

15Linville SE,Rens E.Vocal tract resonance analysis of aging voice using long-term average spectra[J].J Voice,2001,15:323.

16Ferrand CT.Harmonics-to-noise ratio:An index of vocal aging[J].J Voice,2002,16:480.

17Winkler R,Sendl meier W.EGG open quotient in aging voices:Changes withincreasing chronological age andits perception[J].Logoped Phoniatr Vocol,2006,31:51.

18Hodge SF,Colton RH,Kelley RT.Vocal intensity character-istics in normal and elderly speakers[J].J Voice,2001,15:503.

19Makiyama K,Yoshihashi H,Hirai R,et al.Phonatory func-tion of the elderly determined by intensity-loading test:A comparison with the young[J].Otolaryngology-Head and Neck Surgery,2007,136:888.

20Huber JE.Effects of utterance length and vocal loudness on speech breathing in older adults[J].Respiratory Physiology&Neurobiology,2008,164:323.

21Awan SN.The aging female voice:Acoustic and respiratory data[J].Clin Linguist Phon,2006,20:171.

22Takano S,Ki mura M,Nito T,et al.Clinical analysis of pres-bylarynx-vocal fold atrophy in elderly individuals[J].Auris Nasus Larynx,2010,37:461.

23杨强,李焦兰,黄治物,等.国人嗓音与性激素的关系[J].听力学及言语疾病杂志,1994,2:1.

24Gugatschka M,Kiesler K,Obermayer-Pietsch B,et al.Sex hormones and the elderly mail voice[J].J Voice,2008,22:1.

25Laureano J M,Sa MFS,Ferriani RA,et al.Variations of jit-ter and shi mmmer among women in menacme and post meno-pausal women[J].J voice,2009,23:687.

26Amir O,Biron-Shental T.The i mpact of hormonal fluctua-tions on female vocal folds[J].Curr Opin Otolaryngol Head Neck Surg,2004,12:180.

27Newman SR,Butler J,Hammond EH,et al.Preli minary report on hormone receptors in the human vocal fold[J].JVoice,2000,14:72.

28Kosztya-Hojna1B,Andrzejewska A,Rutkowski R,et al.Morphological aspect of voice disturbances of aged persons coexisting hypopharynx cancer[J].Folia Histochemica Et Cytobiologica,2007,45:221.

29Sato K,Hirano M,Nakashi ma T.Age-related changes of collagenous fibers in the human vocal fold mucosa[J].Ann Otol Rhinol Laryngol,2002,111:15.

30Awd Allah RS,Dkhil MA,Farhoud E.Fibroblasts in the human vocal fold mucosa:An ultrastructural study of diffe-rent age groups[J].Singapore Med J,2009;50:201.

31Kosztyla-Hojna B,Andrzejewska A,Rogowski M.Evalua-tion of the ultrastructure of the vocal folds mucosain patients with presbyphonia[J].Otolaryngol Pol,2002,56:239.

32Paulsen F,Ki mpel M,Lockemann U,et al.Effects of ageing on the insertion zones of the human vocal fold[J].J Anat,2000,196:41.

33Buter JE,Hammond TH,Gray SD.Gender-related diffe-rences of hyalluronic acid distributionin the human vocal fold[J].The Laryngoscope,2001,111:907.

34Abdelkafy WM,Smith JQ,Henriquez OA.Age-related changes in the murine larynx:Initial validation of a mouse model[J].Ann Otol Rhinol Laryngol,2007,116:618.

35Hirano S,Bless DM,del Rio AM,et al.Therapeutic poten-tial of growth factors for aging voice[J].Laryngoscope,2004,114:2161.

36Mc Mullen CA,Andrade FH.Functional and morphological evidence of age-related denervation in rat laryngeal muscles[J].J Gerontol A Biol Sci Med Sci,2009,64:435.

37Connor NP,Suzuki T,Lee K,et al.Neuromuscular junction changes in rat thyroarytenoid muscle[J].Ann Otol Rhinol Laryngol,2002,111:579.

38Suzuki T,Connor NP,Lee K,et al.Age-related altera-tions in myosin heavy chainisoforms in rat intrinsic laryngeal muscles[J].Ann Otol Rhinol Laryngol,2002,111:962.

39Mc Mullen CA,Andrade FH.Contractile dysfunction and al-tered metabolic profile of the aging rat thyroarytenoid muscle[J].J Appl Physiol,2006,100:602.

40Diamond J,Skaggs J,Manaligod J M.Free-radical damage:A possible mechanism of laryngeal aging[J].Ear Nose Throat J,2002,81:531.

41Kersing W,Jennekens FG.Age-related changes in human thyroarytenoid muscles:A histological and histochemical study[J].Eur Arch Otorhinolaryngol,2004,261:386.

42Tomita H,Nakashi ma T,Maeda A,et al.Age related chan-ges in the distribution of laryngeal glands in the human adult larynx[J].Auris Nasus Larynx,2006,33:289.

43Sato K,Hirano M.Age-related changes in the human la-ryngeal glands[J].Ann Otol Rhinol Laryngol,1998,107:525.

44Makiyama K,Yoshihashi H,Park R,et al.Assessment ofphonatory function by the airway interruption method:Age-related changes[J].Otolaryngol Head Neck Surg,2006,134:407.

45Huber JE,Spruill J III.Age-related changes to speech breathing with increased vocal loudness[J].Journal of Speech,Language,and Hearing Research,2008,51:651.

46Nagai H,Ota F,Konopacki R,et al.Discoordination of la-ryngeal and respiratory movements in aged rats[J].American Journal of Otolaryngology-Head and Neck Medicine and Surgery,2005,26:377.

47Meurer EM,Oso′rio Wender MC,von Eye Corleta H,et al.Phono-articulatory variations of women in reproductive age and post menopausal[J].J Voice,2004,18:369.

48Shigeta Y,Ogawa T,Venturin J,et al.Gender-and age-based differences in computerized tomographic measure-ments of the oropharynx[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod,2008,106:563.

49Xue SA,Hao GJ.Changes in the human vocal tract due to aging and the acoustic correlates of speech production:A pi-lot study[J].J Speech Lang Hear Res,2003,46:689.

50Plank C,Schneider S,Eysholdt U,et al.Voice and healthre-lated quality of life in the elderly[J].J Voice,2010,1:4.

51Berg EE,Hapnerr E,Klein A,et al.Voice therapyi mproves quality of life in age-related dysphonia:A case-control study[J].J Voice,2008,22:70.

52Hirano S,Nagai H,Tateya I,et al.Regeneration of aged vocal folds with basic fibroblast growthfactor in a rat model:Apreli minary report[J].Ann Otol Rhinol Laryngol,2005,114:304.

53Hirano S,Kishi moto Y,Suehiro A,et al.Regeneration of aged vocal fold:First human case treated with fibroblast growth factor[J].The Laryngoscope,2009,119:197.

54Belafsky P,Post ma GN.Vocal fold augmentation with calci-um hydroxylapatite[J].Otolaryngol Head Neck Surgery,2004,131:351.

55Luu Q,Tsai V,Mangunta V,et al.Safety of percutaneous injection of bovine dermal crosslinked collagen for glottic in-sufficiency[J].Otolaryngology-Head and Neck Surgery,2007,136:445.

56Flint PW,Nakagawa H,Shiotani A,et al.Effects of insulin-like growthfactor-1gene transfer on myosin heavy chains in denervated rat laryngeal muscle[J].Laryngoscope,2004,114:368.

57Motoyoshi K,Hyodo M,Yamagata T,et al.Restoring vo-cal fold movement after transection andi mmediate suturing of the recurrent laryngeal nerve withlocal application of basic fi-broblast growthfactor:An experi mental studyin the rat[J].Laryngoscope,2004,114:1247.