鼓室内注入类固醇激素补救治疗突发性聋的文献Meta分析

Intratympanic Steroid in Idiopathic Sudden Sensorineural Hearing Loss as Salvage Treatment:A Meta-analysis

黄冠;华清泉;

1:武汉大学人民医院耳鼻咽喉-头颈外科

摘要

目的评价鼓室内注入类固醇激素补救治疗突发性聋的疗效及安全性。方法通过对Cochrane图书馆、PubMed、EMbase、CBM、万方全文数据库进行计算机检索以及手工检索,对所纳入的所有应用鼓室内注入类固醇激素补救治疗突发性聋文献的随机对照试验结果(randomized controlled trials,RCTs)进行Meta分析。结果共检索到9篇文献、425例患者(426耳)符合纳入标准。Meta分析结果显示,鼓室内注入类固醇激素补救治疗突发性聋的有效率均高于对照组[RR(95%CI)分别为10.86(4.06,29.4)、7.32(1.37,39.28)、2.10(1.00,4.37)、8.13(1.20,55.61)]。有5篇文献共报道了7例该疗法的并发症,主要为注射后短暂眩晕(4例)、耳部烧灼感(1例)、耳垂部丘疹(1例)、中耳炎(1例)。结论虽然鼓室内注入类固醇激素补救治疗突发性聋的有效率有高于其他治疗方法的趋势,但由于纳入的随机对照试验质量普遍较低,因此,该疗法的疗效及安全性还需更多高质量的大样本、多中心的随机对照试验来进一步证实。

关键词

鼓室内;类固醇激素;突发性聋;Meta分析

基金项目(Foundation):

作者

黄冠;华清泉;

参考文献

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黄冠华清泉