凋亡抑制蛋白Livin及Survivin在中耳胆脂瘤上皮的表达及意义

杨宁;蒋立新;

1:暨南大学附属第一医院耳鼻咽喉头颈外科

摘要
目的探讨凋亡抑制蛋白Livin、Survivin在中耳胆脂瘤上皮的表达及与细胞凋亡的关系。方法应用免疫组织化学二步法检测25例中耳胆脂瘤标本(实验组)及15例外耳道正常皮肤组织(对照组)中Livin及Sur-vivin的表达;采用末端转移酶介导的原位缺口末端标记染色(TUNEL)技术检测Livin及Survivin在两种组织中的表达及细胞的凋亡情况。结果与正常外耳道皮肤组织相比,Livin及Survivin蛋白在胆脂瘤上皮的表达均明显下调(P<0.01),细胞凋亡显著高于正常上皮组织(P<0.01);Livin及Survivin的表达与凋亡呈负相关。结论 Livin及Survivin在中耳胆脂瘤中的表达明显下调,可能与胆脂瘤上皮细胞凋亡有关。
关键词
中耳;胆脂瘤;凋亡;Livin;Survivin
基金项目(Foundation):
作者
杨宁;蒋立新;
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中耳胆脂瘤凋亡LivinSurvivin

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杨宁蒋立新