耳蜗传入通路在耳蜗信号编码中的意义
陈熹;余力生;李兴启;
1:北京大学人民医院耳鼻咽喉科
2:解放军总医院耳鼻咽喉科研究所





1 Puel JL.The inner hair cell synaptic complex:physiology,pharmacology and new therapeutic strategies[J].Audiol Neu-rootol,2002,7:49.
2侯志强,余力生,李兴启.外侧橄榄耳蜗束在内毛细胞下突触复合体中的调控作用[J].听力学及言语疾病杂志,2007,15:416.
3 Moser T,Beutner D.Kinetics of exocytosis and endocytosisat the cochlear inner hair cell afferent synapse of the mouse[J].Proe Natl Acad Sci,2000,97:883.
4 Fuchs PA,Glowatzki E,Moser T.The afferent synapse ofcochlear haircells[J].Current Opinion in Neurobiology,2003,13:452.
5 Sobkowicz HM,August BK,Slapnick SM.Synaptic arrange-ments between inner hair cells and tunnel fibers in the mousecochlea[J].Synapse,2004,52:299.
6 Gil-Loyzaga PL.Neurotransmitter of the olivocochlear lat-eral efferent system:with an emphasis on dopamine[J].ActaOtolaryngol,1995,115:222.
7 Khimich D,Nouvian R,Pujol R,et al.Hair cell synaptic rib-bons are essential for synchronous auditory signaling[J].Na-ture,2005,434:889.
8 Nordang L,Oestreicher E,Arnold W,et al.Glutamate is theafferent neurotransmitter in the human cochlea[J].Acta Oto-laryngol,2000,120:359.
9 Palmada M,Centelles JJ.Excitatory amino acid neurotrans-mission pathway for metabolism,storage and reuptake of glu-tamate in brain[J].Front Biosci,1998,20:701.
10 Puel JL.Chemical synaptic transmission in the cochlea[J].Prog Neurobiol,1995,47:449.
11 Zheng XY,Henderson D,Mc Fadden SL,et al.Auditorynerve fiberresponses following chronic cochlear de-efferen-tation[J].J CompNeurol,1999,406:72.
12 Ruel J,Wang J,Demêmes D,et al.Dopamine transporter isessential for the maintenance of spontaneous activity of audi-tory nerve neurones and their responsiveness to sound stimu-lation[J].Journal of Neurochemistry,2006,97:190.
13 Johnson SL.Tonotopic variation in the calcium dependence ofneurotransmitter release and vesicle pool replenishment at mam-malian auditory ribbon synapses[J].J Neurosci,2008,28:7 670.
14郗昕,李兴启.耳蜗的信息编码[M].见:李兴启,主编.耳蜗病理生理学.北京:人民军医出版社,2011.187~196.
15 Davis RL,Liu Q.Complex primary afferents:What the dis-tribution of electrophysiologically-relevant phenotypes with-in the spiral ganglion tells us about peripheral neural coding[J].Hear Res,2011.Uan 27.[Epub ahead of print]
16 Nelken I.Processing of complex sounds in the auditory sys-tem[J].Curr Opin Neurobiol,2008,18:413.
17 Rodriguez,FA,Read HL,Escabi MA.Spectral and temporalmodulation tradeoff in the inferior colliculus[J].J Neuro-physiol,2010,103:887.
18 Kandler K.Tonotopic reorganization of developing auditorybrainstem circuits[J].Nat Neurosci,2009,12:711.
19 Starr A,Picton TW,Sininger Y,et al.Auditory neuropa-thy[J].Brain,1996,119:741.
20 Starr A,Sininger YS,Pratt H.The varieties of auditory neu-ropathy[J].J Basic Clin Physiol Pharmacol,2000,11:215.
21李兴启,孙勍.关于听神经病之我见[J].听力学及言语疾病杂志,2003,11:241.
22 Berlin CI,Hood L,Rose K.On renaming auditory neuropathy asauditory dyssynchrony[J].Audiol Today,2001,13:15.
23 Zhang X,Carney LH.Analysis of models for the synapse be-tween the inner hair cell and the auditory nerve[J].J AcoustSoc Am,2005,118:1 540.
24李兴启,申卫东,原红艳,等.从内毛细胞下突触复合体结构和功能看听神经病的发病机制及部位[J].听力学及言语疾病杂志,2005,13:223.
25冀飞,陈艾婷,赵阳,等,耳蜗电图和ABR在听神经病诊断中的应用研究[J].临床耳鼻咽喉头颈外科杂志,2010,10:447.
26 Zeng FG,Kong YY,Henry J,et al.Perceptual consequences o fdisrupted auditory nerve activity[J].J Neurophysiol,2005,93:3 050.
27 Darrow KN,Simons EJ,Dodds L,et al.Dopaminergic innerva-tion of the mouse inner ear:evidence for a separate cytochemicalgroup of cochlear efferent fibers[J].2006,498:403.
28 Halmos G,Horvath T,Polony G,et al.The role of N-methyl-D-aspartate receptors and nitric oxide in cochleardopamine release[J].Neuroscience,2008,154:796.
29郭玲伶,余力生,李兴启.多巴胺受体在耳蜗中的分布及其功能[J].国际耳鼻咽喉头颈外科杂志,2009,33:205.
30 Niu X,Canlon B.The signal transduction pathway for thedopamine D1 receptor in the guinea-pig cochlea[J].Neuro-science,2006,137:981.
31 Sun W,Salvi RJ.Dopamine modulates sodium currents in cochle-ar spiral ganglion neurons[J].Neuroreport,2001,12:803.
32侯志强,余力生,李兴启.多巴胺对豚鼠耳蜗谷氨酸受体NM-DA NR1和NMDA NR2A的调节作用[J].听力学及言语疾病杂志,2010,18:153.
33 Lezcano N,Mrzljak L,Eubanks SP.Dual signaling regula-ted by calcyon,a D1 dopamine receptor interacting protein[J].Science,2000,287:1 660.
34侯志强,余力生,李兴启,等.多巴胺对豚鼠听觉传入神经的抑制作用及其频率选择性[J].中华耳鼻咽喉头颈外科杂志,2008,43:601.
35 Ruel J,Nouvian R,Gervais d’Aldin C,et al.Dopamineinhibi-tion of auditory nerve activity in the adult mammalian cochlea[J].Eur J Neurosci,2001,14:977.
36郭玲伶,余力生,李兴启.多巴胺对豚鼠噪声性听力损失的保护作用[J].中国耳鼻咽喉头颈外科,2010,17:411.
37 Mulders WH,Robertson D.Dopaminergic olivocochlear neu-rons originate in the high frequency region of the lateral supe-rior olive of guinea pigs[J].Hear Res,2004,187:122.
38 Simon E.Functional anatomy of the cochlear nerve and thecentral auditory system[J].Neurochirurgie,2009,55:120.
39 Sumner CJ,Lopez-Poveda EA,O'Mard LP,et al.Adapta-tion in a revised inner-hair cell model[J].J Acoust Soc Am,2003,113:893.
40 Niu X,Tahera Y,Canlon B.Environmental enrichment tosound activates dopaminergic pathways in the auditory system[J].Physiology&Behavior,2007,92:34.