突发性聋患者急性期听皮层代谢~1H-MRS研究

~1HMRS Study of Auditory Cortex in Patients with Sudden Sensorineural Hearing Loss

陈贤明;梁永辉;陈自谦;倪萍;

1:南京军区福州总医院耳鼻咽喉-头颈外科

2:南京军区福州总医院医学影像科

3:南京军区福州总医院医学工程科

摘要
目的利用氢质子磁共振波谱(hydrogen proton magnetic resonance spectroscopy,1 H-MRS)技术观察突发性聋患者急性期听皮层代谢变化。方法选取单侧突发性聋患者20例(右侧12例,左侧8例)和10例正常志愿者行1 H-MRS检测,测定双侧颞横回N-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱(Cho)、谷氨酰胺和谷氨复合物(Glx)的峰下面积并计算NAA/Cr、Cho/Cr、Glx/Cr比值,分析突聋组和对照组之间听皮层代谢的差异。结果突聋组与对照组比较,两侧听皮层NAA/Cr、Cho/Cr比值差异均无统计学意义(P>0.05));突聋组耳聋侧听皮层Glx/Cr比值与对照组比较差异无统计学意义(P>0.05),但聋耳对侧听皮层Glx/Cr比值高于对照组,差异有统计学意义(P<0.05)。结论 1 H-MRS可以在活体状态下检测听觉中枢组织代谢变化,突聋患者聋耳对侧听皮层存在谷氨酸代谢异常。
关键词
突发性聋;听皮层;磁共振波谱
基金项目(Foundation):
福建省自然科学基金(2009Y0041)资助
作者
陈贤明;梁永辉;陈自谦;倪萍;
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陈贤明梁永辉陈自谦倪萍