慢性氟中毒大鼠内耳组织线粒体DNA缺失的实验研究
The Experimental Observations on Mitochondrial DNA Deletion Caused by Chronic Fluorosis in Rats Inner Ear
陶学勇;陈乾美;耿勇;李皓琳;刘敏;翟性友;
1:河南大学第一附属医院耳鼻咽喉科
2:贵阳医学院耳鼻咽喉科
3:中国人民解放军第44医院耳鼻咽喉科
4:新乡市第一人民医院耳鼻咽喉科
摘要关键词基金项目(Foundation):作者参考文献1李健学,曹守仁.地方性氟中毒防治研究进展[J].中国地方病学杂志,1994,13:182.
2谭郁彬.氟对机体代谢及各系统的影响[J].中国地方病防治杂志,1994,9:230.
3 Prezant TR,Agapian JV,Bohlman MC,et al.Mitochondrialri-bosomal RNA mutation associated with both antibiotic-in-duced and non-syndromic deafness[J].Nat Genet,1993,4:289.
4侯铁舟,郭海燕,陶洪,等.小鼠氟牙症分级标准的建立[J].国际口腔医学杂志,2009,36:140.
5僧东杰,陈乾美,刘鲜林,等.大鼠慢性氟中毒听觉损伤的实验观察[J].中华耳科杂志,2008,6:162.
6 Ausabel Frederick M,Kingston Robert E,Seldman J,等,著.金由辛,译.精编分子生物学实验指南[M].北京:科学出版社,1998.30～31.
7 Kemp DT.Otoacoustic emissions,their origin in cochlear func-tion,and use[J].Br Med Bull,2002,63:223.
8 Sediman MD,Bai C,Khan MJ,et al.Mitochondrial DNA asso-ciated with aging and presbyacusis[J].Arch Otolaryngol NeckSurg,1997,123:1 039.
9边建朝,王海明,刘传蛟.自由基损伤及细胞凋亡与氟中毒发病研究进展[J].地方病通报,2003,18:100.
10 Thompson LV.Oxidative stress,mitochondria and mtDNA-mutator micc[J].Exp Gcrontol,2006,41:1 220.
11 Zerwekh JE,Morris AC,Padalino PK,et al.Fluoride rapidlyand transiently raises intracellular calcium in human osteo-blasts[J].Bone Miner Res,1990,5(suppl 1):131.
12 Seidman MD,Anman N,Joshi D,et al.Agerelated hearing lossand its association with reactive oxygen species and mitochondrialDNA damage[J].Acta Otolaryngol,2004,552(Suppl):16.