重组腺病毒载体介导外源性XIAP抑制听皮层GABA能神经元凋亡与老年性聋相关性研究进展

胡玥;姬长友;陈继川;

1:第三军医大学大坪医院野战外科研究所耳鼻咽喉-头颈外科

摘要
<正>老年性聋是一类随年龄增长而出现的以双耳进行性高频听力下降为主要表现的慢性退行性疾病。研究表明,大于65岁的老人中,40%以上受老年性聋困扰[1,2]。随着中国逐步进入老龄化社会,老年性聋因严重影响老年人的生活质量而受到社会关注。目前,老年性聋的发病机制并不十分清楚,但研究发现外周听觉系统和听觉中枢功能失调共同参与了老年性聋的发病,其中听觉中枢神经细胞凋亡引起听觉中枢功能障碍是老年性聋患者听力下降、语言理解能力降低的
关键词
基金项目(Foundation):
国家自然科学基金资助(30872861)
作者
胡玥;姬长友;陈继川;
参考文献

1 Gates GA,Mills JH.Presbycusis[J].Lancet,2005,366:1 111.

2 Yamasoba T,Someya S,Yamada C,et al.Role of mitochon-drial dysfunction and mitochondrial DNA mutations in age-related hearing loss[J].Hearing Research,2007,226:185.

3 Gates GA,Feeney MP,Mills D.Cross-sectional age-chan-ges of hearing in the elderly[J].Ear and Hearing,2008,29:865.

4 Crook NE,Clem RJ,Miller LK.An apoptosis-inhibiting baculo-virus gene with a zinc finger-like motif[J].Journal of Virology,1993,67:2 168.

5 Holcik M,Gibson H,Korneluk RG.XIAP:Apoptotic brake and promising therapeutic target[J].Apoptosis,2001,6:253.

6 Suzuki Y,Nakabayashi Y,Nakata K,et al.X-linked inhibi-tor of apoptosis protein(XIAP)inhibits caspase-3and-7in distinct modes[J].Journal of Biological Chemistry,2001,276:27 058.

7 Riedl S J,Renatus M,Schwarzenbacher R,et al.Structural basis for the inhibition of caspase-3by XIAP[J].Cell,2001,104:791.

8 Shiozaki EN,Chai J,Rigotti DJ,et al.Mechanism of XIAP-mediated inhibition of caspase-9[J].Molecular Cell,2003,11:519.

9 Cryns V,Yuan J.Protease to die for[J].Genes and Develop-ment,1998,12:1 551.

10 Hofer-Warbinek R,Schmid JA,Stehlik C,et al.Activa-tion of NF-κB by XIAP,the X chromosome-linked inhibi-tor of apoptosis,in endothelial cells involves TAK1[J].Jour-nal of Biological Chemistry,2000,275:22 064.

11 Papa S,Zazzeroni F,Pham CG,et al.Linking JNK signaling to NF-κB:A key to survival[J].Journal of Cell Science,2004,117:5 197.

12 Chen B,Zhong Y,Peng W,et al.Age-related changes in the central auditory system:Comparison of d-galactose-in-duced aging rats and naturally aging rats[J].Brain Research,2010,1 344:c43.

13周媛,谢鼎华,彭斌.年龄相关性听力损失大鼠听皮层、蜗核、耳蜗SOD、MDA变化及神经细胞凋亡初步观察[J].听力学及言语疾病杂志,2009,17:58.

14肖伯奎,华清泉,王勤瑛.正常大鼠听觉中枢四种氨基酸类神经递质测定[J].听力学及言语疾病杂志,2007,15:475.

15 Larry FH,Jeremy GT,Jennifer LP,et al.Processing of broadband stimuli across A1layers in young and aged rats[J].Hearing Research,2010,264:79.

16 Wang J,Menchenton T,Yin S,et al.Over-expression of X-linked inhibitor of apoptosis protein slows presbycusis in C57BL/6Jmice[J].Neurobiology of Aging,2010,31:1 238.

17李洪波,陈继川,姬长友.C57BL/6J小鼠初级听皮层神经元凋亡与caspase-3表达的年龄相关性改变[J].听力学及言语疾病杂志,2009,17:248.

18李洪波,陈继川,姬长友.XIAP在年龄相关性听力减退C57BL/6J小鼠初级听皮质的表达[J].中华耳科学杂志,2009,7:85.

19 Atorrasagasti C,Malvicini M,Aquino JB,et al.Overexpres-sion of SPARC obliterates the in vivo tumorigenicity of hu-man hepatocellular carcinoma cells[J].Int J Cancer,2010,126:2 726.

20 McCoy K,Tatsis N,Korioth-Schmitz B,et a1.Effect of preexisting immunity to adenovirus human serotype 5anti-gens on the immune responses of nonhuman primates to vac-cine regimens based on human-or chimpanzee-derived ade-novirus vectors[J].Journal of Virology,2007,81:6 594.

21 Hidajat R,Kuate S,Venzon D.Construction and immunoge-nicity of replication-competent adenovirus 5host range mu-tant recombinants expressing HIV-1gp160of SF162and TV1strains[J].Vaccine,2010,28:3 963.

22 Liu XY,Qiu SB,Zou WG,et al.Effective gene-virothera-py for complete eradication of tumor mediated by the combi-nation of hTRAIL(TNFSF10)and plasminogen k5[J].Mo-lecular Therapy,2005,11:531.

23 Hashimoto M,Hisano Y.Directional gene-transfer into the brain by an adenoviral vector tagged with magnetic nanoparti-cles[J].Journal of Neuroscience Methods,2011,194:316.

24 Hermann DM,Kilic E,Kügler S,et al.Adenovirus-media-ted GDNF and CNTF pretreatment protects against striatal Injury following transient middle cerebral artery occlusion in Mice[J].Neurobiology of Disease,2001,8:655.

25 Hermann DM,Kilic E,Kügler S,et al.Adenovirus-media-ted Glial cell line-derived neurotrophic factor(GDNF)ex-pression protects against subsequent cortical cold injury in rats[J].Neurobiology of Disease,2001,8:964.

26战梅,杨仁池.凋亡抑制蛋白XIAP的研究进展[J]国外医学.生理、病理科学与临床分册,2004,24:5.

27 Zadro-Lamoureux LA,Zacks DN,Baker AN,et al.Effects on XIAP retinal detachment-induced photorecepter apopto-sis[J].Investigative Ophthalmology and Visual Science,2009,50:1 448.

28 Wang T,Wang J,Yin C,et al.Down-regulation of Nogo receptor promotes functional recovery by enhancing axonal connectivity after experimental stroke in rats[J].Brain Re-search,2010,1 360(C):147.

29 Hildebrandt S,Schmidt A,Stoll A,,et al,Targeting of neu-ral stem cells in the hippocampus of adult rats by custom-made Ad vectors[J].Brain Structure and Function,2010,25:105.

30 Tatsuya N,Takashi O,Kuniko S,et al.Distinct patterns of gene transfer to gerbil hippocampus with recombinant adeno-associated virus type 2and 5[J].Neuroscience Letters,2003,340:153.

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胡玥姬长友陈继川