年龄相关性听力损失小鼠耳蜗毛细胞的凋亡机制
Mechanism of Hair Cell Apoptosis in Age-related Hearing Loss Mouse Cochlea
张少强;李胜利;闫利英;李随勤;李白芽;朱宏亮;郑庆印;
1:西安交通大学医学院第一附属医院耳鼻咽喉-头颈外科
2:西安交通大学医学院第二附属医院耳鼻咽喉科-头颈外科
3:西安交通大学神经科学研究中心
4:Case Western Reserve University School of Medicine
摘要关键词基金项目(Foundation):作者参考文献1Idrizbegovic E,Bogdanovic N,Willott JF,et al.Agerelated increases in calcium-binding protein i mmunoreactivity in the cochlear nucleus of hearingi mpaired C57BL/6J mice[J].Neu-robiol Aging,2004,25,1085.
2Popelar J,Groh D,Pelanova J,et al.Age-related changesin cochlear and brainstem auditory functions in Fischer344rats[J].Neurobiol Aging,2006,27,490.
3Li SL,Shao QZ,Si WL,et al.Assessment criteria for rotated stereociliary bundlesinthe guinea pig cochlea[J].Otol Neuro-tol,2008,29:86.
4Noben-Trauth K,Zheng QY,Johnson KR,et al.Mdfw:A deafness susceptibility locus that interacts with deaf waddler(dfw)[J].Genomics,1997,44:266.
5Ji menez AM,Stagner BB,Martin GK,et al.Age-related loss of distortion product otoacoustic emissions in four mouse strains[J].Hearing Research,1999,138:91.
6熊敏,何青莲,汪建,等.Caspase-3在老年豚鼠耳蜗螺旋神经节细胞的表达[J].中国组织化学与细胞化学杂志,2006,15:4.
7Pickles JO.Mutationin mitochondrial DNAas a cause of pres-byacusis[J].Audiol Neurootol,2004,9:23.
8Liu VP,Staecker H,Stupak H,et al.Caspaseinhibitors pre-vent cispla2tininduced apoptosis of auditory sensory cells[J].Neuroreport,1998.
9Wang J,Puel JL.From cochlear cell death pathways to new pharmacological therapies[J].Mini Rev Med Chem,2008,8:1006.
10Taylor RB,Nevill G,Forge A.Rapid hair cell loss:A mouse model for cochlear lesions[J].JARO,2007,9:44.
11Jiang H,Sha SH,Forge A,et al.Caspase-independent pathways of hair cell deathinduced by kanamycinin vivo[J].Cell Death Differ,2006,13:20.
12Zheng YL,Ikeda K,Nakamura M,et al.Endonuclease cleavage of DNAin the aged cochlea of Mongolian gerbil[J].Hearing Research1998,126:11.
13Nicotera TM,Hu BH,Henderson D.The caspase pathway in noise-induced apoptosis of the chinchilla cochlea[J].JARO2003,4:466.
14Wang J,Lloyd Faulconbridge RV,Fetoni A,et al.Local ap-plication of sodium thiosulfate prevents cisplatin-induced hearing loss in the guinea pig[J].Neuropharmacology,2003,45:380.
15Hu BH,Henderson D,Nicotera TM.Extremely rapidinduc-tion of outer hair cell apoptosis in the chinchilla cochlea fol-lowing exposure to i mpulse noise[J].Hearing Research,2006,211:16.