大鼠双侧耳蜗毁损后下丘核生长相关蛋白表达研究
The Expression of Growth Associated Protein-43 in Inferior Colliculus in Rats after Bilateral Cochlear Ablation
郜元坤;华清泉;廖华;李孟;
1:武汉大学人民医院耳鼻咽喉-头颈外科





1Wiese UH,Ruth JL,Emson PC.Differential expression of growth-associated protein(GAP-43)mRNAin rat pri mary sensory neurons after peripheral nerve lesion:A non-radioactive in situ hybrization study[J].Brain Res,1992,592:141.
2Alvarado JC,Fuentes-Santamaria V,Franklin SR,et al.Synaptophysin and insulin-like growth factor-1i mmunos-taingin the central nucleus of the inferior colliculus in adult ferrets following unilateral cochlear removal:A densitometric analysis[J].Synapse,2007,61:288.
3Alvarado JC,Fuentes-Santamaria V,Henkel CK,et al.Al-terations in calretinin i mmunostaing in the ferret superior oli-vary complex after cochlear ablation[J].The Journal of Com-parative Neurology,2004,470:63.
4Pollak GD,Park TJ.The effects of GABAergicinhibition on monaural response properties of neurons in the mustache bat's inferior colliculus[J].Hear Res,1993,65:99.
5Salvi RJ,Wang J,Ding D.Auditory plasticity and hyperactiv-ity following cochlear damage[J].Hear Res,2000,261.
6Gutfreund Y,Zheng W,Knudsen EI.Gated visual input to the central auditory system[J].Science,2002,297:1556.
7Knudsen EI.Instructed learning in the auditory localization pathway of the barn owl[J].Nature,2002,417:322.
8Kull mann PH,Ene FA,Kandler K.Glycinergic and GABA ergic calciumresponses in the developing lateral superior olive[J].Eur J Neurosci,2002,15:1093.
9Alvarado JC,Fuentes-Santamaria V,Franklin SR,et al.U-nilateral deafeningin adult ferret results in upregulationin the calretinini mmunoreactivity in the inferior colliculus[J].Neu-roscience,2005,136:957.
10Syka J.Plastic changes in the central auditory system after hearing loss,restoration of function,and during learning[J].Physiol Rev,2002,82:601.
11Huang X,Chen S,Tietz E.I mmunocytochemical detection of regional protein changes in rat brain sections using com-puter-assisted i mage analysis[J].J Histochem Cytochem,1996,44:981.
12孙久荣,余瑞元,刘文胜,等.迷路损伤增强大鼠前庭内侧核生长相关蛋白mRNA水平[J].生理学报,1998,50:587.
13McGuir CB,Snipes GJ,Norden JJ.Light-microscopic i mmu-nolo-calization of the growth-and plasticity-associated protein GAP-43in the developing rat brain[J].Brain Res,1988,469:277.
14Chen B,Wang JF,Sun X.Regulation of GAP-43expression by chronic desipramine treat ment in rat cultured hippocampal cells[J].Biol paychiatry,2003,3:530.
15Faison MO,Preozzi EF,Caran N,et al.Axonal localization of delta Ca/cal m-Odulin dependent protein kinase II in develo-ping P19neurons[J].Int J Dev-Neurosic,2002,20:585.
16Michler SA,Illing RB.Acoustic trauma Induces reemergence of the growth-and plasticity-associated protein GAP-43in the rat auditory brainstem[J].J Comp Neurol,2002,451:250.
17Chen TJ,Huang CW,Wang DC.Co-induction of growth-associated protein GAP-43and neuronal nitric oxide syn-thase in the cochlear nucleus following cochleotomy[J].Brain Res,2004,158:151.
18Mossop JE,Wilson MJ,Caspary DM,et al.Down-regulation of in hibition following unilateral deafening[J].Hear Res,2000,147:183.
19Illing RB,Cao QL,Fomter CR,et al.Auditory brainstem:De-velopment and plasticity of GAP-43mRNA expression in the rat[J].J Comp Neurol,1999,412:353.