1Alexiou C,Arnold W,Fauser C,et al.Sudden sensorineural hearing loss does application of glucocorticoids make sense[J]?Arch Oto-laryngol Head Neck Surg,2001,127:253.

2Dodson KM,Woodson E,Sismanis A.Intratympanic steroid perfusion for the treat ment of Me′nie`re's disease:a retrospec-tive study[J].Ear Nose Throat J,2004,83:394.

3Canlon B,Meltser I,Johansson P,et al.Glucocorticoid recep-tors modulate auditory sensitivity to acoustic trauma[J].Hear Res,2006,226:21.

4Bartholome B,Spies CM,Gaber T,et al.Membrane glucocorti-coid receptors(mGCR)are expressed in normal human peri-pheral blood mononuclear cells and up-regulated after in vitro sti mulation and in patients with rheumatoid arthritis[J].FASEB J,2004,18:70.

5Bray PJ,Cotton RG.Variations of the human glucocorticoid re-ceptor gene(NR3C1):Pathological andin vitro mutations and polymorphisms[J].Hum Mutat,2003,21:557.

6Gametchu B,Watson CS.Correlation of membrane glucocorti-coid receptor levels with glucocorticoid-induced apoptotic competence using mutant leukemic and lymphoma cells lines[J].J Cell Biochem,2002,87:133.

7Russcher H,Dal m VA,de Jong FH,et al.Associations be-tween promoter usage and altemative:Splicing of the glu-cocorticoid receptor gene[J].J Mol Endocrinol,2007,38:91.

8Chrousos GP,Kino T.Intracellular glucocorticoid signaling:A formerly si mple system turns stochastic[J].Sci Stke,2005,306:48.

9Oakley RH,Sar M,Cidlowski JA.The human glucocorticoid receptor beta isoform.Expression,biochemical properties,and putative function[J].J Biol Chem,1996,271:9550.

10Yudt MR,Cidlowski JA.Molecular identitication and charac-terization ofαandβforms of the glucocorticoid receptor[J].J Mol Endocrinol,2001,15:1093.

11Bandyopadhyay G,Standaert ML,Sajan MP,et al.Depen-dence of insulin-sti mulated glucose transporter4translocation on3-phosphoinositide-dependent protein kinase-1and its target threonine-410in the activationloop of protein kinase C-ze-ta[J].J Mol Endocrinol,1999,13:1766.

12Beger C,Gerdes K,Lauten M,et al.Expression and structural analysis of glucocorticoid receptor isoform gamma in human leukaemia cells using an isoform specific real-ti me polyme-rase chain reaction approach[J].Br J Haematol,2003,122:245.

13de Lange P,Segeren CM,Koper J W,et al.Expression in he-matological malignancies of a glucocorticoid receptor splice variant that augments glucocorticoid receptor-mediated effects in transfected cells[J].Cancer Res,2001,61:3937.

14Koga Y,Mat suzaki A,Suminoe A,et al.Differential mRNA expression of glucocorticoid receptor alpha and beta is associ-ated with glucocorticoid sensitivity of acutelymphoblasticleu-kemia in children[J].Pediatr Blood Cancer,2005,45:121.

15Lewis-Tuffin LJ,Cidlowski JA.The physiology of human glucocorticoid receptor beta(hGR beta)and glucocorticoid resistance[J].Ann N Y Acad Sci,2006,1069:1.

16Kofler R,Schmidt S,Kofler A,et al.Resistance to glucocorti-coid-induced apoptosis in lymphoblastic leukemia[J].J En-docrinol,2003,178:19.

17Pujols L,Alobid I,Bentiz P,et al.Regulation of glucocorticoid receptor in nasal polyps by systemic andintranasal glucocorti-coids[J].Allergy,2008,63:1377.

18Andreae J,Tripmacher R,Weltrich R,et al.Effect of Glu-cocorticoid therapy on glucocorticoid receptors in children with autoi mmune diseases[J].Pediatr Res,2001,49:130.

19Wallace AD,Cidlowski JA.Proteasome-mediated glucocor-ticoid receptor degradation restricts transcriptional signaling by glucocorticoids[J].J Biol Chem,2001,276:42714.

20Oakley RH,Cidlowski JA.Homologous down regulation of the glucocorticoid receptor:The molecular machinery[J].Crit Rev Eukaryot Gene Expr,1993,3:63.

21刘宇健,宋亮年,卢建.糖皮质激素对糖皮质激素受体α和βmRNA表达的调节作用[J].中国病理生理杂志,2002,18:234.

22郁博,何威,张斌.地塞米松对HaCaT细胞糖皮质激素受体β表达的影响[J].重庆医学,2008,37:610.

23Oakley RH,Jewell CM,Yudt MR,et al.The dominant nega-tive activity of the human glucocorticoid receptor beta iso-form.Specificity and mechanisms of action[J].J Biol Chem,1999,274:27857.

24Torrego A,Pujols L,Roca-Ferrer J,et al.Glucocorticoid re-ceptor isoforms alpha and beta in in vitro cytokine-induced glucocorticoid insensitivity[J].Am J Respir Crit Care Med,2004,170:420.

25Rabbitt JL,Calhoun WJ.Allergic cytokines regulate expres-sion of glucocorticoid receptor[GR]alpha and beta isoforms[J].J Allergy Clin I mmunol,2006,117:S254.

26Webster JC,Oakley RH,Jewell CM,et al.Proinflammatory cyto-kines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform:A mechanismfor the generation of glucocorticoid re-sistance[J].Proc Natl Acad Sci USA,2001,98:6865.

27Rarey KE,Curtis LM.Receptors for glucocorticoidsinthe hu-man inner ear[J].Otolaryngol Head Neck Surg,1996,115:38.

28Shi mazaki T,Ichi miya I,Suzuki M,et al.Localization of glu-cocorticoid receptors in the murine inner ear[J].Ann Otol Rhinol Laryngol,2002,111:1133.

29Terunuma T,Kawauchi S,Kajihara M,et al.Effect of acoustic stress on glucocorticoid receptor mRNAin the cochlea of the guinea pig[J].Brain Res Mol Brain Res,2003,120:65.

30Tahera Y,Meltser I,Johansson P,et al.NF-kappa B media-ted glucocorticoid response in the inner ear after acoustic trauma[J].J Neurosci Res,2006,83:1066.

31Ki m SH,Ki m KX,Raveendran NN,et al.Regulation of epi-thelial sodium channel(ENaC)-mediated sodiumtransport by glucocorticoidsin reissner's membrane epithelium[J].AmJ Physiol Cell Physiol,2009,296:C544.

32Pondugula SR,Raveendran NN,Ergonul Z,et al.Glucocorti-coid regulation of genes in the amiloride-sensitive sodium transport pathway by semicircular canal duct epithelium of neonatal rat[J].Physiol Genomics,2006,24:114.

33Tahera Y,Meltser I,Johansson P,et al.Sound conditioning protects hearing by activating the hypothalamic-pituitary-adrenal axis[J].Neurobiology Dis,2007,25:189.

34Zou J,Curtis LM,Yao X,et al.Glucocorticoid receptor ex-pressionin the postnatal rat cochlea[J].Hear Res,1995,87:220.